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Génie biomédical
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Understanding Computational Costs of Cellular-Level Brain Tissue Simulations Through Analytical Performance Models

Felix Schürmann, Francesco Cremonesi

Computational modeling and simulation have become essential tools in the quest to better understand the brain's makeup and to decipher the causal interrelations of its components. The breadth of biochemical and biophysical processes and structures in the b ...

HUMANA PRESS INC2020

A synchrotron X-ray imaging strategy to map large animal brains

Giorgio Margaritondo, Ying Chen

Mapping the large neural networks of animal and human brains is a fundamental but so far elusive task, because of the massive amount of data and the consequent prohibitively long image taking and processing times. We developed an effective strategy called ...

2020

The Scientific Case for Brain Simulations

Felix Schürmann, Michele Migliore, Alain Destexhe

A key element of the European Union's Human Brain Project (HBP) and other large-scale brain research projects is the simulation of large-scale model networks of neurons. Here, we argue why such simulations will likely be indispensable for bridging the scal ...

CELL PRESS2019

A null model of the mouse whole-neocortex micro-connectome

Henry Markram, Eilif Benjamin Muller, Michael Reimann, Ying Shi, Huanxiang Lu

In connectomics, the study of the network structure of connected neurons, great advances are being made on two different scales: that of macro- and meso-scale connectomics, studying the connectivity between populations of neurons, and that of micro-scale c ...

Nature Research2019

The Connection Between the Nervous System and Machines: Commentary

Giacomo Valle

Decades of technological developments have populated the field of brain-machine interfaces and neuroprosthetics with several replacement strategies, neural modulation treatments, and rehabilitation techniques to improve the quality of life for patients aff ...

2019

Computational characteristics and hardware implications of brain tissue simulations

Francesco Cremonesi

Understanding the link between the brain's anatomy and its function through computer simulations of neural tissue models is a widely used approach in computational neuroscience. This technique enables rapid prototyping and testing of hypotheses, allowing r ...

EPFL2019

Data-driven reconstruction of a point neuron mouse brain

Csaba Erö

In this work, we present a semi-automatic method to reconstruct a mouse whole-brain model at the point-neuron level by integrating a wide array of biological data. Our process has three parts: cell position and type assignment, connectivity mapping, and si ...

EPFL2018

Accelerating Data Analysis in Simulation Neuroscience with Big Data Technologies

Felix Schürmann, Judit Planas Carbonell, Fabien Jonathan Delalondre

Important progress in computational sciences has been made possible recently thanks to the increasing computing power of high performance systems. Following this trend, larger scientific studies, like brain tissue simulations, will continue to grow in the ...

Springer International Publishing2018

Neuroprosthetics to support impaired hand functions: A multidisciplinary approach combining brain-machine interfaces and wearable exoskeletons

Luca Randazzo

Neuroprosthetics, the discipline that aims at interfacing neural systems to artificially engineered devices, has witnessed in recent years important advancements towards the ultimate goal of augmenting and restoring human functions through technology and a ...

EPFL2018

Electronic solutions for power system emulation

Guillaume Olivier Lanz

Nowadays electric power systems are subject to continuous changes and the needs in the power generation and delivery service are constantly increasing, with a higher complexity of a progressively more distributed network. Because the impact of a failure ca ...

EPFL2017

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Neuroprosthetics to support impaired hand functions: A multidisciplinary approach combining brain-machine interfaces and wearable exoskeletons

Luca Randazzo

EPFL2018