Publications associées à Vue de l'évolution centrée sur les gènes

Protein Structural Information and Evolutionary Landscape by In Vitro Evolution

Protein structure is tightly intertwined with function according to the laws of evolution. Understanding how structure determines function has been the aim of structural biology for decades. Here, we have wondered instead whether it is possible to exploit ...

OXFORD UNIV PRESS2020

Theoretical foundations of forward feature selection methods based on mutual information

Francisco Santos Paredes Quartin de Macedo

Feature selection problems arise in a variety of applications, such as microarray analysis, clinical prediction, text categorization, image classification and face recognition, multi-label learning, and classification of internet traffic. Among the various ...

ELSEVIER SCIENCE BV2019

Multigene expression in stable CHO cell pools generated with the piggyBac transposon system

Florian Maria Wurm, David Hacker, Sowmya Balasubramanian

Heterogenous populations of recombinant cells (cell pools) stably expressing 1-4 transgenes were generated from Chinese hamster overy (CHO) cells with the piggyBac (PB) transposon system. The cell pools produced different combinations of three model protei ...

American Chemical Society2016

MAR Elements and Transposons for Improved Transgene Integration and Expression

Nicolas Mermod, Déborah Ley, Niamh Harraghy

Reliable and long-term expression of transgenes remain significant challenges for gene therapy and biotechnology applications, especially when antibiotic selection procedures are not applicable. In this context, transposons represent attractive gene transf ...

2013

A Quantitative Test of Hamilton's Rule for the Evolution of Altruism

Dario Floreano, Laurent Keller, Markus Waibel

The evolution of altruism is a fundamental and enduring puzzle in biology. In a seminal paper Hamilton showed that altruism can be selected for when rb − c>0, where c is the fitness cost to the altruist, b is the fitness benefit to the beneficiary, and r i ...

Public Library of Science2011