Concept
Fardeau génétique
Publications associées (34)
Environment-dependent epistasis increases phenotypic diversity in gene regulatory networks
Mutations to gene regulatory networks can be maladaptive or a source of evolutionary novelty. Epistasis con-founds our understanding of how mutations affect the expression patterns of gene regulatory networks, a chal-lenge exacerbated by the dependence of ...
AMER ASSOC ADVANCEMENT SCIENCE2023Identifying genetic and dietary modulators of metabolic disorders using systems genetics
Long-term consumption of lipid-rich foods can contribute to common metabolic diseases and systemic low-grade inflammation. However, dietary responses and the development of non-communicable diseases are shaped by genetic factors and gene-by-environment int ...
EPFL2023Optimization of elastic wave propagation in a reconfigurable medium by genetic algorithms with adaptive mutation probability
Romain Christophe Rémy Fleury, Janez Rus
We introduce a reconfigurable medium for the manipulation of elastic propagation properties of Lamb waves. It is based on a shape memory polymer (SMP) with temperature-dependent Young's modulus. Waves are excited by a laser pulse and detected by a laser vi ...
IOP Publishing Ltd2023Genomic consequences of colonisation, migration and genetic drift in barn owl insular populations of the eastern Mediterranean
Nicolas Jean Philippe Guex, Eléonore Lavanchy
The study of insular populations was key in the development of evolutionary theory. The successful colonisation of an island depends on the geographic context, and specific characteristics of the organism and the island, but also on stochastic processes. A ...
2022Spatial areas of genotype probability: Predicting the spatial distribution of adaptive genetic variants under future climatic conditions
Stéphane Joost, Oliver Michele Selmoni, Estelle Rochat
In a context of rapid global change, one of the key components for the survival of species is their genetic evolutionary potential for adaptation. Many methods have been developed to identify genetic variants underpinning adaptation to climate, but few too ...
WILEY2021Adapt or Perish: Evolutionary Rescue in a Gradually Deteriorating Environment
Anne-Florence Raphaëlle Bitbol, Loïc Marrec
We investigate the evolutionary rescue of a microbial population in a gradually deteriorating environment, through a combination of analytical calculations and stochastic simulations. We consider a population destined for extinction in the absence of mutan ...
2020Elucidating regulatory mechanisms shaping the transcriptome and proteome of the gut immune response in Drosophila melanogaster
Work on Drosophila melanogaster paved the way to our current understanding of modern genetics. Since then, this model organism has contributed greatly to various fields such as neurobiology, development, and immunology. The discovery and analysis of the va ...
EPFL2019Responses of permanent grasslands to drought during the plant growing season: combining agronomic, functional and ecophysiological approaches
Extreme summer drought events are predicted to increase in intensity and frequency within the current century. The resulting water scarcity could dramatically impact human activities related to agriculture, due to the strong relationship between precipitat ...
EPFL2019Genetic determinants of healthy human immune variance: from humoral response to microbiome diversity
Identifying the drivers of the observed interindividual variability of the human immune system is crucial to our understanding of infectious and immune-mediated diseases. The contribution of genetic and non-genetic factors to immunological differences betw ...
EPFL2018Two sides of the same coin: A population genetics perspective on lethal mutagenesis and mutational meltdown
Jeffrey David Jensen, Claudia Bank, Sebastian Matuszewski, Nicky Louise Ormond
The extinction of RNA virus populations upon application of a mutagenic drug is frequently referred to as evidence for the existence of an error threshold, above which the population cannot sustain the mutational load. To explain the extinction process aft ...
Oxford Univ Press2017