Concept

Clonage thérapeutique

Publications associées (118)

Understanding engraftment of cultured epidermal stem cells

The epidermis and its appendages protect our body from environmental hazards. Cells generated in the basal layer continuously replace the terminally differentiated keratinocytes that are shed off the epidermal surface. Long-term renewal depends on specific ...

EPFL2008

Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types

Friedrich Beermann, Anne Grapin-Botton

All pancreatic endocrine cells, producing glucagon, insulin, somatostatin, or PP, differentiate from Pdx1+ progenitors that transiently express Neurogenin3. To understand whether the competence of pancreatic progenitors changes over time, we generated tran ...

2007

Design of Self-organizing Bio-inspired Systems

Daniel Mange, Joël Rossier

Self-organizing bio-inspired systems borrow three structural principles characteristic of living organisms: multicellular architecture, cellular division, and cellular differentiation. Implemented in silicon according to these principles, our cellular syst ...

IEEE Computer Society2007

Self-organizing Systems Based on Bio-inspired Properties

Daniel Mange, Joël Rossier

Bio-inspiration borrows three properties characteristic of living organisms: multicellular architecture, cellular division, and cellular differentiation. Implemented in silicon according to these properties, our self-organizing systems are able to grow, to ...

Springer2007

Bone tissue engineering using fetal cell therapy

Dominique Pioletti

Different cell sources for bone tissue engineering are reviewed. In particular, adult cell source strategies have been based on the implantation of unfractionated fresh bone marrow; purified, culture expanded mesenchymal stem cells, differentiated osteobla ...

2006

Stem cells and their niche: a matter of fate

Olaia Maria Naveiras Torres-Quiroga

Embryonic stem cells provide an in vitro model for developmental biologists to study cell fate decisions during ontogenesis, while somatic stem cells allow physiologists to understand tissue homeostasis in the adult. The behavior of stem cells is dependent ...

Springer Verlag2006

Characterization of Fibra-Cel® packed-bed bioreactors for the culture of CHO cells

Frédéric Meuwly

Today, more than 30 products using a manufacturing process based on mammalian cell culture have been approved for human therapy. Most of these products are currently supplied with stirred tank bioreactors operated in batch or fed-batch mode. However, the b ...

EPFL2006

Bone-marrow haematopoietic stem cell niches

Anne Wilson

Adult stem cells hold many promises for future clinical applications and regenerative medicine. The haematopoietic stem cell (HSC) is the best-characterized somatic stem cell so far, but in vitro expansion has been unsuccessful, limiting the future therape ...

2006

Influence of Hydrogen-Bonding Substituents on the Cytotoxicity of RAPTA Compounds

Paul Joseph Dyson, Ursula Röthlisberger, Ivano Tavernelli, Christian Gossens, Claudine Scolaro, Sébastien Rochat, Antoine Dorcier, Gianni Sava

A new series of organometallic ruthenium(II)-arene compounds of the type RuCl2(η6-arene)(phosphine) (phosphine = 1,3,5-triaza-7-phosphaadamantane, PTA, and 3,7-diacetly-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane, DAPTA) with different ...

2006

Treatment of acetaminophen-induced acute liver failure in the mouse with conditionally immortalized human hepatocytes

Didier Trono

BACKGROUND/AIMS: Liver failure is a life threatening condition currently treated by palliative measures and, when applicable, organ transplantation. The use of a bioartificial organ capable of fulfilling the main functions of the liver would represent an a ...

Elsevier2005

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