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Publications associées (29)

Density and phase-purity of α-TCP obtained by sintering of nano-crystalline powder

Dense and polished samples are sometimes used to test the in vitro biological response of biomaterials. However, their production can be challenging, for example for α-tricalcium phosphate (α-TCP), a commonly-used bone graft substitute. In this particular ...

2024

Cysteine-Cysteine Cross-Conjugation of both Peptides and Proteins with a Bifunctional Hypervalent Iodine-Electrophilic Reagent

Jérôme Waser, Stefano Nicolai, Abhaya Kumar Mishra

Peptide and protein bioconjugation sees ever-growing applications in the pharmaceutical sector. Novel strategies and reagents that can address the chemo- and regioselectivity issues inherent to these biomolecules, while delivering stable and functionalizab ...

Weinheim2023

A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes

Kathryn Hess Bellwald, Lida Kanari, Martina Scolamiero

Environmental cues influence the highly dynamic morphology of microglia. Strategies to characterize these changes usually involve user-selected morphometric features, which preclude the identification of a spectrum of context-dependent morphological phenot ...

NATURE PORTFOLIO2022

The role of plasma-molecule interactions on power and particle balance during detachment on the TCV tokamak

Basil Duval, Christian Gabriel Theiler, Artur Perek, Kevin Henricus Annemarie Verhaegh, Mirko Wensing

This paper shows experimental results from the TCV tokamak that indicate plasma-molecule interactions involving D2+

IOP PUBLISHING LTD2021

Pencil Graphite Needle-Shaped Biosensor for Anaesthetic Monitoring in Human Serum

Sandro Carrara, Danilo Demarchi, Simone Aiassa

Direct and online continuous monitoring of anaesthetic intake by the patient's blood stream improves practices in the critical procedure of anaesthesia. Several systems have been proposed to address this challenge. Electrochemical techniques are highly app ...

IEEE2020

Lack of effect on ambulation of dalfampridine-ER (4-AP) treatment in adult SMA patients

SMA is a genetically determined motor system disorder that results in muscle weakness, selective motor neuron death, muscle atrophy, and impaired functional mobility. In SMA model systems, long-term treatment with 4-aminopyridine (4-AP) has been shown to i ...

PERGAMON-ELSEVIER SCIENCE LTD2020

Magnetic Resonance Spectroscopy in Schizophrenia: Evidence for Glutamatergic Dysfunction and Impaired Energy Metabolism

Lijing Xin, João Miguel das Neves Duarte

In the past couple of decades, major efforts were made to increase reliability of metabolic assessments by magnetic resonance methods. Magnetic resonance spectroscopy (MRS) has been valuable for providing in vivo evidence and investigating biomarkers in ne ...

2019

IoT Bio-Electronic Multi-Panel Device for On-line Monitoring of Anaesthesia Delivery

Francesca Stradolini

After a failure of "One-Size-Fits-All" approach on traditional treatment of diseases, the age of multi-faceted personalized medicine came into being for tailoring therapy to get the best response in the highest safety margin. Personalized drug dosage is on ...

EPFL2018

Cleaning strategy for carbon-based electrodes: Long-term propofol monitoring in human serum

Giovanni De Micheli, Giovanni Boero, Francesca Stradolini, Irene Taurino, Tugba Kilic

In this work, we present a novel electrochemical cleaning procedure for long-term electrochemical monitoring of propofol by using boron-doped diamond (BDD) and pencil graphite electrode (PGE). Propofol is an anesthetic that is widely used for long-lasting ...

2018

Energy metabolism in the rat cortex under thiopental anaesthesia measured

Rolf Gruetter, João Miguel das Neves Duarte, Nathalie Just, Sarah Catherine Sonnay

Barbiturates, commonly used as general anaesthetics, depress neuronal activity and thus cerebral metabolism. Moreover, they are likely to disrupt the metabolic support of astrocytes to neurons, as well as the uptake of nutrients from circulation. By employ ...

Wiley-Blackwell2017

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