Concept

Inhibiteur de la recapture

Publications associées (36)

Synthesis of [(2S,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]-5-methylfuran-4-carboxylic acid derivatives: New leads as selective beta-galactosidase inhibitors

Pierre Vogel, Inmaculada Robina, Raynald Demange

The preparation of [(2S,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]furan derivatives in a stereoselective route starting from D-glucose and ethyl acetoacetate is presented. Ethyl ester (6), N,N-diethylamide (7) and N-isopropylamide (8) have been tested towards 25 ...

2002

New leads for selective inhibitors of alpha-L-fucosidases. Synthesis and glycosidase inhibitory activities of [(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]furan derivatives

Pierre Vogel, Inmaculada Robina, Raynald Demange

Readily derived from D-glucose, 5-[(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]-2-methyl-3-furoic esters and amides are selective and competitive inhibitors (K(i)greater than or equal to3 muM) Of alpha -L-fucosidase from bovine epididymis and from human placen ...

2001

The cellular bases of functional brain imaging: evidence for astrocyte-neuron metabolic coupling

Pierre Magistretti, Luc Pellerin

Signals detected with functional brain imaging techniques are based on the coupling between neuronal activity and energy metabolism. Positron emission tomography signals detect blood flow, oxygen consumption and glucose utilization associated with neuronal ...

1997

Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA

Michel Aguet

Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be associated with aggressive behavior in men of a Dutch family. A line of transgenic mice was isolated in which transgene integratio ...

1995

Alcohol production from whey permeate by yeast and by a thermophile strain

Urs von Stockar

The potential of EtOH [64-17-5] fermn. of whey permeate as a means of whey disposal and utilization in Switzerland was explored. The effluent lactose content of unconcd. permeate can be reduced to 2% of the original value by continuous fermn. with Kluyvero ...

1985

Effect of 6-hydroxydopamine lesions on norepinephrine-induced [3H]glycogen hydrolysis in mouse cortical slices

Pierre Magistretti

The effects of norepinephrine (NE) on in vitro [3H]glycogenolysis were assessed in slices of cerebral cortex from mice whose cortical noradrenergic innervation had been severely reduced by intracisternal 6-hydroxydopamine (6-OHDA) injections. A supersensit ...

1983

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