Concept

Restriction digest

Publications associées (32)

PSGL-1 is an evolutionarily conserved antiviral restriction factor

The arms race between viruses and their hosts shaped the evolutionary history and the genome composition of both parties. Restriction factors are the first-line antiviral effectors encoded by the host genomes and are often conserved through evolution to pr ...

AMER SOC MICROBIOLOGY2023

Establishing a Ternary System for Optical Monitoring of DNA-Protein Interactions with Single-Walled Carbon Nanotubes

Shang-Jung Wu

DNA-protein interactions lie at the crux of life's essential processes. As such, various technologies have been developed to characterize these interactions. The distinct advantages of these technologies can be leveraged to study different facets of these ...

EPFL2020

High-content, cell-by-cell assessment of HER2 overexpression and amplification: a tool for intratumoral heterogeneity detection in breast cancer

Martinus Gijs, Daniel Migliozzi, Huu Tuan Nguyen

Immunohistochemistry and fluorescence in situ hybridization are the two standard methods for human epidermal growth factor receptor 2 (HER2) assessment. However, they have severe limitations to assess quantitatively intratumoral heterogeneity (ITH) when mu ...

NATURE PUBLISHING GROUP2019

Restriction endonuclease AgeI is a monomer which dimerizes to cleave DNA

Virginija Jovaisaite

Although all Type II restriction endonucleases catalyze phosphodiester bond hydrolysis within or close to their DNA target sites, they form different oligomeric assemblies ranging from monomers, dimers, tetramers to higher order oligomers to generate a dou ...

Oxford University Press (OUP)2017

A Dirichlet problem involving the divergence operatord

Bernard Dacorogna, Gyula Csató

We consider the problem {div u + (a; u) = f in Omega u = u(0) on partial derivative Omega. We show that if curl a (x(0)) not equal for some x(0) epsilon Omega, then the problem is solvable without restriction on f. We also discuss the regularity of the sol ...

Elsevier Science Bv2016

Compact Corrugated Feedhorns With High Gaussian Coupling Efficiency and-60 dB Sidelobes

We demonstrate that very high performance, extremely compact, scalar corrugated feedhorns can be designed and constructed by optimizing the excitation and phasing of the HE11, HE12, and HE13 modes near the throat of the horn while limiting excitation of hi ...

Institute of Electrical and Electronics Engineers2016

Integrating Gene Synthesis and MITOMI for Rapid Protein Engineering

Matthew Christopher Blackburn

The research described within this thesis is primarily motivated by two fields of science with reversed, yet complementary, approaches to addressing the same essential objective: manipulating and understanding the complex program of life. Whereas synthetic ...

EPFL2016

Distributed Programming via Safe Closure Passing

Philipp Haller

Programming systems incorporating aspects of functional programming, e.g., higher-order func- tions, are becoming increasingly popular for large-scale distributed programming. New frameworks such as Apache Spark leverage functional techniques to provide hi ...

2015

Optimized distributed implementation of multiparty interactions with Restriction

Joseph Sifakis

Using high level coordination primitives allows enhanced expressiveness of component-based frameworks to cope with the inherent complexity of present-day systems designs. Nonetheless, their distributed implementation raises multiple issues, regarding both ...

Elsevier2015

Global Solutions to a Non-Local Diffusion Equation with Quadratic Non-Linearity

Joachim Krieger

In this paper we prove the global in time well-posedness of the following non-local diffusion equation with

\alpha\, \varepsilon [0, 2/3)

\partial_tu=\{(-\Delta)^{-1}u\}\Delta u+\alpha u^2, \,\, u(t=0)=u_0

. The initial condition

u_0

is positive, rad ...

2012

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