In this paper we prove the global in time well-posedness of the following non-local diffusion equation with : . The initial condition is positive, radial, and non-increasing with u_0 \varepsilon L^1 \cap L^{2+(\mathbb{R^3) for some small . There is no size restriction on . This model problem appears of interest due to its structural similarity with Landau’s equation from plasma physics, and moreover its radically different behavior from the semi-linear Heat equation: .