Concept

Réaction de Wurtz

Publications associées (13)

Chiral Alkyl Amine Synthesis via Catalytic Enantioselective Hydroalkylation of Enecarbamates

Chiral alkyl amines are omnipresent as bioactive molecules and synthetic intermediates. The catalytic and enantioselective synthesis of alkyl amines from readily accessible precursors is challenging. Here we develop a nickel-catalyzed hydroalkylation metho ...

AMER CHEMICAL SOC2021

Copper-Catalyzed Cyanomethylation of Allylic Alcohols with Concomitant 1,2-Aryl Migration: Efficient Synthesis of Functionalized Ketones Containing an α-Quaternary Center

Qian Wang, Jieping Zhu, Ala Bunescu

A copper-catalyzed alkylation of allylic alcohols by alkyl nitriles with concomitant 1,2-aryl migration was developed. Formation of the alkyl nitrile radical was followed by its intermolecular addition to alkenes and the migration of a vicinal aryl group w ...

Wiley-Blackwell2015

Arene ruthenium and pentamethylcyclopentadienyl rhodium and iridium complexes containing N,O-chelating ligands derived from piroxicam: Synthesis, molecular structure and cytotoxicity

Paul Joseph Dyson, Tina Riedel

The non-steroidal anti-inflammatory and anti-arthritic drug piroxicam (LH) reacts with arene ruthenium dichloride dimers in refluxing dichloromethane to give the complexes [(eta(6)-arene)Ru(eta(2)-N,O-L)Cl] (3: arene = C6H5Me, 4: arene = p-MeC6H4Pri, 5: ar ...

Elsevier2014

Synthesis of Saturated Heterocycles via Metal-Catalyzed Formal Cycloaddition Reactions That Generate a C–N or C–O Bond

Jérôme Waser

In this section, the synthesis of saturated N- and O-heterocycles via formal cycloaddition is presented. The main focus is on metal-catalyzed reactions involving C–C or C–X σ bond cleavage in three- or four-membered rings. After a fast presentation of pion ...

Springer Verlag2013

Copper-catalyzed cross coupling of functionalized alkyl halides and tosylates with secondary and tertiary alkyl Grignard reagents

Xile Hu, Lucas-Alexandre Stern, Peng Ren

A copper-based method is highly efficient for the cross-coupling of alkyl electrophiles with secondary and tertiary alkyl Grignard reagents. The method is distinguished by its broad substrate scope and high functional group tolerance. ...

Wiley-V C H Verlag Gmbh2012

A Well-Defined Ni Pincer Catalyst for Cross Coupling of Non-Activated Alkyl Halides and Direct C-H Alkylation

Oleg Vechorkin

Carbon-carbon bond forming reactions are among the most important and useful methods for organic synthesis. During the last years, significant progress has been made in this field. Whereas many catalysts were developed for the coupling of aryl, alkenyl, an ...

EPFL2011

Ni-Catalyzed Cross Coupling of Non-Activated and Functionalized Alkyl Halides with Alkyl Grignard Reagents

Xile Hu, Oleg Vechorkin

The title reaction is realized by using an isolated NiII complex (1). The catalysis tolerates a wide range of important functional groups that are often incompatible with Grignard reagents in cross-coupling reactions. ...

2009

Palladium-Catalyzed Desulfitative Mizoroki-Heck Coupling Reactions of Sulfonyl Chlorides with Olefins in a Nitrile-functionalized Ionic Liquid

Paul Joseph Dyson, Pierre Vogel, Zhaofu Fei, Dongbin Zhao, Chandra Mouleeswara Rao Volla

Aryl and alkenyl sulfonyl chlorides can be used in Heck-Mizoroki-type couplings with mono- and disubstituted olefins in a nitrile-functionalized ionic liquid, viz. [C3CNpy][Tf2N]. Advantages over previously reported methods include: (1) use of a cheap cat ...

2006

Atmospheric heterogeneous reactions of chlorine and bromine containing molecules

Arnaud Aguzzi

This thesis deals with a laboratory study of heterogeneous reactions involving bromine and chlorine containing reservoir species on alkali salt substrates which are relevant to the marine boundary layer, and on ice substrates which are relevant to the lowe ...

EPFL2001

The Heterogeneous Kinetics of the Reactions ClONO

Hubert van den Bergh, Michel Rossi, Raoul Oppliger

The kinetics and mechanism of the title heterogeneous halogen exchange reactions of potential atmospheric importance have been studied under molecular flow conditions in a FEP Teflon-coated Knudsen flow reactor on HX (X = Cl, Br, I) - doped ice condensed f ...

2000

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