Concept
Cerebral atrophy
Publications associées (52)
A Microfluidic Brain Interface for In Vivo Recording of Neurochemical Activity
Guillaume Cédric Yves Petitpierre
Neurological disorders have a strong negative impact on the quality of life of affected patients, their close relatives as well as on the health economic system. Early diagnosis associated with better treatment outcomes remain difficult to reach. Similarly ...
EPFL2017Hyperpolarized MRS: New tool to study real-time brain function and metabolism
Mor-Miri Mishkovsky, Arnaud Comment
The advent of dissolution dynamic nuclear polarization (DNP) led to the emergence of a new kind of magnetic resonance (MR) measurements providing the opportunity to probe metabolism in vivo in real time. It has been shown that, following the injection of h ...
Elsevier2017Lactoferrin during lactation reduces lipopolysaccharide-induced brain injury
Lactoferrin (Lf), component of maternal milk, has antioxidant, anti-inflammatory and antimicrobial properties. Neuroprotective effects of Lf on the immature brain have been recently shown in rodent models of intrauterine growth restriction and cerebral hyp ...
Wiley-Blackwell2016Erythropoietin Restores Long-Term Neurocognitive Function Involving Mechanisms of Neuronal Plasticity in a Model of Hyperoxia-Induced Preterm Brain Injury
Cerebral white and grey matter injury is the leading cause of an adverse neurodevelopmental outcome in prematurely born infants. High oxygen concentrations have been shown to contribute to the pathogenesis of neonatal brain damage. Here, we focused on moto ...
Hindawi Limited2016A subcutaneous cellular implant for passive immunization against amyloid-beta reduces brain amyloid and tau pathologies
Patrick Aebischer, Bernard Schneider, Aurélien Lathuilière, Vanessa Laversenne, Marco Stampanoni
Passive immunization against toxic misfolded proteins could offer protection against neurodegenerative disease. LathuiliSre et al. report the development of a retrievable device to encapsulate cells secreting recombinant anti-amyloid-beta antibodies. When ...
Oxford Univ Press2016Structural plasticity of remote cortical brain regions is determined by connectivity to the primary lesion in subcortical stroke
Cortical atrophy as demonstrated by measurement of cortical thickness (CT) is a hallmark of various neurodegenerative diseases. In the wake of an acute ischemic stroke, brain architecture undergoes dynamic changes that can be tracked by structural and func ...
2015A Multi-Contrast MRI Study of Microstructural Brain Damage in Patients with Mild Cognitive Impairment
Meritxell Bach Cuadra, Reto Meuli, Alessandro Daducci, Cristina Granziera, Daniel Andreas Schmitter, Alexis Roche, Guillaume Bonnier
Objectives: The aim of this study was to investigate pathological mechanisms underlying brain tissue alterations in mild cognitive impairment (MCI) using multi-contrast 3 T magnetic resonance imaging (MRI). Methods: Forty-two MCI patients and 77 healthy co ...
Elsevier2015alpha-Synuclein strains cause distinct synucleinopathies after local and systemic administration
Misfolded protein aggregates represent a continuum with overlapping features in neurodegenerative diseases, but differences in protein components and affected brain regions(1). The molecular hallmark of synucleinopathies such as Parkinson's disease, dement ...
Nature Publishing Group2015Physiological noise in human cerebellar fMRI
Rolf Gruetter, Wietske Van der Zwaag, João Pedro Forjaco Jorge, Denis Butticaz
Objectives To compare physiological noise contributions in cerebellar and cerebral regions of interest in high-resolution functional magnetic resonance imaging (fMRI) data acquired at 7T, to estimate the need for physiological noise removal in cerebellar f ...
Springer Verlag2015Identification of new Presenilin-1 phosphosites: implication for gamma-secretase activity and A beta production
Romain Hamelin, Patrick Fraering, Marc Moniatte, Mitko Dimitrov, Sébastien Mosser, Alexandre Matz, Blanka Halamoda
An important pathological hallmark of Alzheimer's disease (AD) is the deposition of amyloid-beta (A) peptides in the brain parenchyma, leading to neuronal death and impaired learning and memory. The protease -secretase is responsible for the intramembrane ...
Wiley-Blackwell2015