Concept
Acide alpha-cétoglutarique
Publications associées (32)
Influence of Amino Acid Substitutions in Capsid Proteins of Coxsackievirus B5 on Free Chlorine and Thermal Inactivation
Tamar Kohn, Aleksandar Antanasijevic, Kiruthika Kumar, Shotaro Torii
The sensitivity of enteroviruses to disinfectants varies among genetically similar variants and coincides with amino acid changes in capsid proteins, although the effect of individual substitutions remains unknown. Here, we employed reverse genetics to inv ...
2024Metabolic, cellular and defense responses to single and co-exposure to carbamazepine and methylmercury in Dreissena polymorpha
Carbamazepine (CBZ) and Hg are widespread and persistent micropollutants in aquatic environments. Both pollutants are known to trigger similar toxicity mechanisms, e.g. reactive oxygen species (ROS) production. Here, their effects were assessed in the zebr ...
2022Epigenetic remodelling of enhancers in response to estrogen deprivation and re-stimulation
Estrogen hormones are implicated in a majority of breast cancers and estrogen receptor alpha (ER), the main nuclear factor mediating estrogen signaling, orchestrates a complex molecular circuitry that is not yet fully elucidated. Here, we investigated geno ...
OXFORD UNIV PRESS2021Microfluidic system for Caenorhabditis elegans culture and oxygen consumption rate measurements
Martinus Gijs, Thomas Lehnert, Matteo Cornaglia, Roger Philippe Krenger
Mitochondrial respiration is a key signature for the assessment of mitochondrial functioning and mitochondrial dysfunction is related to many diseases including metabolic syndrome and aging-associated conditions. Here, we present a microfluidic Caenorhabdi ...
ROYAL SOC CHEMISTRY2020Detection of D-amino acid oxidase using hyperpolarized molecular probes
Rolf Gruetter, Hikari Ananda Infinity Yoshihara, Alice Radaelli
D-amino acid oxidase (DAO) is an enzyme that catalyzes the degradation of D-amino acids in the body. Here, we explored the possibility of detecting D-amino acid oxidase activity by monitoring its metabolism in the rat kidney after a bolus injection of hype ...
2018Hyperpolarization of 2-keto[1-13C]isocaproate for in vivo studies with photo-induced radicals
Rolf Gruetter, Mor-Miri Mishkovsky, Arnaud Comment, Hikari Ananda Infinity Yoshihara
Hyperpolarized 2-keto[1-13C]isocaproate (KIC) provides a means to probe brain nitrogen homeostasis and to assess molecular signatures of tumors. The dynamic nuclear polarization process requires a free-radical polarizing agent, and samples are typically do ...
2017MRS studies of neuroenergetics and glutamate/glutamine exchange in rats: Extensions to hyperammonemic models
Cristina Ramona Cudalbu, Bernard Lanz, Veronika Rackayová
In vivo Magnetic Resonance Spectroscopy is a useful tool to characterize brain biochemistry as well as its alteration in a large number of major central nervous system diseases. The present review will focus on the study of the glutamate-glutamine cycle, a ...
Elsevier2017Study of cortical energy metabolism during sensory stimulation-induced brain activity by ¹³C magnetic resonance spectroscopy in vivo
Cerebral function is associated with high metabolic activity that is supported by continuous supply of oxygen and glucose from the blood. Coupling between brain energy metabolism and neuronal activity has been studied extensively during the past decades. N ...
EPFL2017