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Crigler-Najjar type 1 disease (CN-1) is a genetic disorder characterized by high levels of unconjugated bilirubin due to the absence of hepatic UDPglucuronosyltransferase (UGT1) activity. Here we show that in vivo neonatal hepatocyte transduction with a le ...
The most common type of sustained arrhythmia is atrial fibrillation (AF), affecting about 2% of the general population and 8% to 11% of the elderly, more than 65 years of age. The treatment of atrial arrythmia is still based on empirical considerations and ...
The ability to overexpress full-length huntingtin or large fragments represents an important challenge to mimic Huntington's pathology and reproduce all stages of the disease in a time frame compatible with rodent life span. In the present study, tetracycl ...
In group-living animals, aggregation favours interactions as well as information exchanges between individuals, and allows thus the emergence of complex collective behaviors. In previous works, a model of a self-enhanced aggregation was deduced from experi ...
In silico analysis reveals that most protective antigens expressed by the antituberculous vaccine Mycobacterium bovis BCG (BCG) are conserved in M. avium, supporting the hypothesis that exposure to environmental mycobacteria generates cross-reactive immune ...
Species movement and occupancy of habitat patches are dependent on landscape permeability. Some land-use types (e.g., roads) may be barriers to animal movement. Analyses of the effect of landscape structure on patch occupancy usually use circular buffers a ...
Modulation of chromatin structure has long been proposed to underlie the colinear regulation of Hox genes during animal development. In a recent paper, Chambeyron and Bickmore explore this possibility in retinoic acid-induced ES cells. They show that, whil ...
Suppose we train an animal in a conditioning experiment. Can one predict how a given animal, under given experimental conditions, would perform the task? Since various factors such as stress, motivation, genetic background, and previous errors in task perf ...
The study of mouse models is crucial for the functional annotation of the human genome. The recent improvements in mouse genetics now moved the bottleneck in mouse functional genomics from the generation of mutant mice lines to the phenotypic analysis of t ...
A common method to induce enhanced short-term endogenous porphyrin synthesis and accumulation in cell is the topical, systemic application of 5-aminolevulinic acid or one of its derivatives. This circumvents the intravenous administration of photosensitize ...
