Publications associées à Théorie neutraliste de l'évolution

How Structural and Physicochemical Determinants Shape Sequence Constraints in a Functional Enzyme

Matteo Dal Peraro, Luciano Andres Abriata

The need for interfacing structural biology and biophysics to molecular evolution is being increasingly recognized. One part of the big problem is to understand how physics and chemistry shape the sequence space available to functional proteins, while sati ...

Public Library Science2015

Local Conformational Switching of Supramolecular Networks at the Solid/Liquid Interface

Klaus Kern, Magalí Alejandra Lingenfelder, Fernando Pablo Cometto

We use the electric field in a scanning tunneling microscope to manipulate the transition between open and close packed 2D supramolecular networks of neutral molecules in nonpolar media. We found that while the magnitude of the applied field is not decisiv ...

Amer Chemical Soc2015

A Systematic Survey of an Intragenic Epistatic Landscape

Jeffrey David Jensen, Claudia Bank

Mutations are the source of evolutionary variation. The interactions of multiple mutations can have important effects on fitness and evolutionary trajectories. We have recently described the distribution of fitness effects of all single mutations for a nin ...

Oxford Univ Press2015

The Interplay Between Host Genetic Variation, Viral Replication, and Microbial Translocation in Untreated HIV-Infected Individuals

Jacques Fellay, Amalio Telenti, Istvan Bartha

Systemic immune activation, a major determinant of human immunodeficiency virus (HIV) disease progression, is the result of a complex interplay between viral replication, dysregulation of the immune system, and microbial translocation due to gut mucosal da ...

Oxford University Press2015

Unraveling Patterns of Site-to-Site Synonymous Rates Variation and Associated Gene Properties of Protein Domains and Families

Slavica Dimitrieva Janeva

In protein-coding genes, synonymous mutations are often thought not to affect fitness and therefore are not subject to natural selection. Yet increasingly, cases of non-neutral evolution at certain synonymous sites were reported over the last decade. To ev ...

Public Library of Science2014

Continental-Scale Footprint of Balancing and Positive Selection in a Small Rodent (Microtus arvalis)

Matthieu Foll

Genetic adaptation to different environmental conditions is expected to lead to large differences between populations at selected loci, thus providing a signature of positive selection. Whereas balancing selection can maintain polymorphisms over long evolu ...

Public Library of Science2014

Time-dependent density functional theory molecular dynamics simulation of doubly charged uracil in gas phase

Ursula Röthlisberger, Ivano Tavernelli, Pablo Lopez Tarifa

We use time-dependent density functional theory and Born-Oppenheimer molecular dynamics methods to investigate the fragmentation of doubly ionized uracil in gas phase. Different initial electronic excited states of the dication are obtained by removing ele ...

2014

Network Neutrality Inference

Ovidiu Sebastian Mara, Zhiyong Zhang

When can we reason about the neutrality of a network based on external observations? We prove conditions under which it is possible to (a) detect neutrality violations and (b) localize them to specific links, based on external observations. Our insight is ...

2014

Robust Demographic Inference from Genomic and SNP Data

Matthieu Foll

We introduce a flexible and robust simulation-based framework to infer demographic parameters from the site frequency spectrum (SFS) computed on large genomic datasets. We show that our composite-likelihood approach allows one to study evolutionary models ...

Public Library of Science2013

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Théorie neutraliste de l'évolution

How Structural and Physicochemical Determinants Shape Sequence Constraints in a Functional Enzyme

Local Conformational Switching of Supramolecular Networks at the Solid/Liquid Interface

A Systematic Survey of an Intragenic Epistatic Landscape

The Interplay Between Host Genetic Variation, Viral Replication, and Microbial Translocation in Untreated HIV-Infected Individuals

Unraveling Patterns of Site-to-Site Synonymous Rates Variation and Associated Gene Properties of Protein Domains and Families

Continental-Scale Footprint of Balancing and Positive Selection in a Small Rodent (Microtus arvalis)

Time-dependent density functional theory molecular dynamics simulation of doubly charged uracil in gas phase

Network Neutrality Inference

SamBada in Uganda: landscape genomics study of traditional cattle breeds with a large SNP dataset

Robust Demographic Inference from Genomic and SNP Data

Graph Chatbot

Chattez avec Graph Search

Network Neutrality Inference

The Interplay Between Host Genetic Variation, Viral Replication, and Microbial Translocation in Untreated HIV-Infected Individuals

Local Conformational Switching of Supramolecular Networks at the Solid/Liquid Interface

A Systematic Survey of an Intragenic Epistatic Landscape

How Structural and Physicochemical Determinants Shape Sequence Constraints in a Functional Enzyme

Unraveling Patterns of Site-to-Site Synonymous Rates Variation and Associated Gene Properties of Protein Domains and Families

Time-dependent density functional theory molecular dynamics simulation of doubly charged uracil in gas phase

Continental-Scale Footprint of Balancing and Positive Selection in a Small Rodent (Microtus arvalis)

Robust Demographic Inference from Genomic and SNP Data

SamBada in Uganda: landscape genomics study of traditional cattle breeds with a large SNP dataset