Concept

Épigénomique

Publications associées (48)

KAP1-mediated epigenetic repression in the forebrain modulates behavioral vulnerability to stress

Maria del Carmen Sandi Perez, Didier Trono, Maria Isabel Cordero Campana, Jean-Charles Bensadoun, Reto Bisaz, Anna Claire Groner, Johan Jakobsson

KAP1 is an essential cofactor of KRAB-zinc finger proteins, a family of vertebrate-specific epigenetic repressors of largely unknown functions encoded in the hundreds by the mouse and human genomes. Here, we report that KAP1 is expressed at high levels and ...

2008

A landscape genomics approach to understanding and predicting species distribution

Stéphane Joost

In habitat modelling, an initial step is to define geoenvironmental variables to be included in a predictive model. According to Guisan and Zimmermann (2000), the selection of predictors can be made either arbitrarily, automatically by stepwise procedures, ...

2008

Identification of CIITA Regulated Genetic Module Dedicated for Antigen Presentation

Philipp Bucher

The class II trans-activator CIITA is a transcriptional co-activator required for the expression of Major Histocompatibility Complex (MHC) genes. Although the latter function is well established, the global target-gene specificity of CIITA had not been def ...

2008

Modeling the Isoelectric Focusing of Peptides in an OFFGEL Multicompartment Cell

Hubert Girault, Niels Erik Lion, Hoang-Trang Lam

In proteomic analysis of complex samples at the peptide level (termed shotgun proteomics), an effective prefractionation is crucial to decrease the complexity of the peptide mixture for further analysis. In this perspective, the high-resolving power of the ...

American Chemical Society2007

Proof of concept for microarray-based detection of DNA-binding oncogenes in cell extracts

Philipp Bucher

The function of DNA-binding proteins is controlled not just by their abundance, but mainly at the level of their activity in terms of their interactions with DNA and protein targets. Moreover, the affinity of such transcription factors to their target sequ ...

2005

The quenching of electrochemiluminescence upon oligonucleotide hybridization

Nico de Rooij

Many genomic assays rely on a distance-dependent interaction between luminescent labels, such as luminescence quenching or resonance energy transfer. We studied the interaction between electrochemically excited Ru(bpy) 3 2+ and Cy5 in a hybridization assay ...

2004

A microfluidic platform using molecular beacon-based temperature calibration for thermal dehybridization of surface-bound DNA

Nico de Rooij, Gerardo Turcatti

This work presents a simple microfluidic device with an integrated thin-film heater for studies of DNA hybridization kinetics and double-stranded DNA melting temperature measurements. The heating characteristics of the device were evaluated with a novel, n ...

2004

Differential sensitivity of zinc finger transcription factors MTF-1, Sp1 and Krox-20 to CpG methylation of their binding sites

Freddy Radtke

Cytosine methylation at CpG sites is often negatively correlated with mammalian gene activity. Many transcription factors whose DNA binding site contains one or more CpG dinucleotides are no longer able to efficiently bind DNA when the site is methylated. ...

1996

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