Concept
Hélice (géométrie)
Publications associées (38)
The fundamental relation between electrohelicity and molecular optical activity
Electrohelicity arises in molecules such as allene and spiropentadiene when their symmetry is reduced and helical frontier molecular orbitals (MOs) appear. Such molecules are optically active and electrohelicity has been suggested as a possible design prin ...
ROYAL SOC CHEMISTRY2023A Biallelic Truncating Variant in the TPR Domain of GEMIN5 Associated with Intellectual Disability and Cerebral Atrophy
GEMIN5 is a multifunctional RNA-binding protein required for the assembly of survival motor neurons. Several bi-allelic truncating and missense variants in this gene are reported to cause a neurodevelopmental disorder characterized by cerebellar atrophy, i ...
2023Landscapes of DNA Mechanics and Genomes
The local physical properties - such as shape and flexibility - of the DNA double-helix is today widely believed to be influenced by nucleic acid sequence in a non-trivial way. Furthermore, there is strong evidence that these properties play a role in many ...
EPFL2023Sequence-dependent structural properties of B-DNA: what have we learned in 40 years?
John Maddocks, Daiva Petkeviciute, Rahul Sharma, Marco Pasi, Paolo Carloni
The structure of B-DNA, the physiological form of the DNA molecule, has been a central topic in biology, chemistry and physics. Far from uniform and rigid, the double helix was revealed as a flexible and structurally polymorphic molecule. Conformational ch ...
London2021Cys-Cys and Cys-Lys Stapling of Unprotected Peptides Enabled by Hypervalent Iodine Reagents
Jérôme Waser, Christian Heinis, Gontran Sangouard, Elija Grinhagena
Easy access to a wide range of structurally diverse stapled peptides is crucial for the development of inhibitors of protein-protein interactions. Herein, we report bis-functional hypervalent iodine reagents for two-component cysteine-cysteine and cysteine ...
2021Unusually Long-Lived Photocharges in Helical Organic Semiconductor Nanostructures
Jürgen Brugger, Andrzej Sienkiewicz, Holger Frauenrath, Valentin Flauraud, Jan Cornelius Brauer, Liangfei Tian, Thomas Schmaltz, Regina Judith Hafner
Photocharge generation and formation of long-lived charge carriers are relevant in photosynthesis, photocatalysis, photovoltaics, and organic electronics. A better understanding of the factors that determine these processes in synthetic polymer semiconduct ...
AMER CHEMICAL SOC2018Controlling the Topological Sector of Magnetic Solitons in Exfoliated Cr1/3NbS2 Crystals
Frédéric Mila, Natalia Chepiga, Fengping Li
We investigate manifestations of topological order in monoaxial helimagnet Cr1/3NbS2 by performing transport measurements on ultrathin crystals. Upon sweeping the magnetic field perpendicularly to the helical axis, crystals thicker than one helix pitch (48 ...
2017Kinetically Trapped Liquid-State Conformers of a Sodiated Model Peptide Observed in the Gas Phase
Thomas Rizzo, Chiara Masellis, Markus Schneider, Carsten Baldauf
We investigate the peptide AcPheAla(5)Lyar(+), a model system for studying helix formation in the gas phase, in order to fully understand the forces that stabilize the helical structure. In particular, we address the question of whether the local fixation ...
2017X-ray structure of a lectin-bound DNA duplex containing an unnatural phenanthrenyl pair
DNA duplexes containing unnatural base-pair surrogates are attractive biomolecular nanomaterials with potentially beneficial photophysical or electronic properties. Herein we report the first X-ray structure of a duplex containing a phen-pair in the center ...
Royal Soc Chemistry2016Structure of the Type VI Secretion System Contractile Sheath
Bacteria use rapid contraction of a long sheath of the type VI secretion system (T6SS) to deliver effectors into a target cell. Here, we present an atomic-resolution structure of a native contracted Vibrio cholerae sheath determined by cryo-electron micros ...
Elsevier BV2015