Publications associées à Nucleic acid notation

Optimised set of oligonucleotides for bulk rna barcoding and sequencing

Bart Deplancke, Vincent Roland Julien Gardeux, Riccardo Dainese, Daniel Alpern

The present invention relates generally to the field of nucleic acid sequencing and provides oligonucleotide molecules and barcodes contained therein. These oligonucleotide molecules and barcodes molecules are useful in sequencing to identify and resolve e ...

2023

Interplay of the mechanical and structural properties of DNA nanostructures determines their electrostatic interactions with lipid membranes

Maartje Martina Cornelia Bastings, Cem Tekin, Diana Kornelia Morzy, Vincenzo Caroprese

Nucleic acids and lipids function in close proximity in biological processes, as well as in nanoengineered constructs for therapeutic applications. As both molecules carry a rich charge profile, and frequently coexist in complex ionic solutions, the electr ...

ROYAL SOC CHEMISTRY2023

Core-shell Structured Chitosan-polyethylenimine Nanoparticles for Gene Delivery: Improved Stability, Cellular Uptake, and Transfection Efficiency

Sandrine Gerber, Perrine Agnes Edith Robin, Laura Camille Louise Nicolle

Gene therapy emerged as a promising treatment option for acquired and inherited diseases. The delivery of nucleic acids relies on vectors that condense and encapsulate their cargo. Especially non-viral gene delivery systems are of increasing interest. Howe ...

2022

A simple micropreparative gel electrophoresis technique for purification of proteins, nucleic acids, and bioconjugates

Ardemis Anoush Boghossian, Sayyed Hashem Sajjadi, Shang-Jung Wu, Vitalijs Zubkovs

The biochemical and biomedical fields hinge on the ability to effectively separate and purify biological macromolecules. Though this need is largely addressed with a variety of chromatographic and electrophoretic purification techniques, such techniques ar ...

2021

Detecting DNA and RNA and Differentiating Single-Nucleotide Variations via Field-Effect Transistors

Nako Nakatsuka, Yang Yang, Bowen Zhu

We detect short oligonucleotides and distinguish between sequences that differ by a single base, using label-free, electronic field-effect transistors (FETs). Our sensing platform utilizes ultrathin-film indium oxide FETs chemically functionalized with sin ...

2020

Regulation of cGAS- and RLR-mediated immunity to nucleic acids

Andrea Ablasser

Pathogen-derived nucleic acids are crucial signals for innate immunity. Despite the structural similarity between those and host nucleic acids, mammalian cells have been able to evolve powerful innate immune signaling pathways that originate from the detec ...

NATURE PUBLISHING GROUP2020

Detecting topological variations of DNA at single-molecule level

Aleksandra Radenovic, Georg Fantner, Adrian Pascal Nievergelt, Ke Liu

In addition to their use in DNA sequencing, ultrathin nanopore membranes have potential applications in detecting topological variations in deoxyribonucleic acid (DNA). This is due to the fact that when topologically edited DNA molecules, driven by electro ...

2019

Electronic Relaxation Dynamics of UV-Photoexcited 2-Aminopurine-Thymine Base Pairs in Watson-Crick and Hoogsteen Conformations

Rebecca Ann Ingle, Hugo Jean Baptiste Marroux

The fluorescent analogue 2-aminopurine (2AP) of the canonical nucleobase adenine (6-aminopurine) base-pairs with thymine (T) without disrupting the helical structure of DNA. It therefore finds frequent use in molecular biology for probing DNA and RNA struc ...

AMER CHEMICAL SOC2019

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Nucleic acid notation

Landscapes of DNA Mechanics and Genomes

Optimised set of oligonucleotides for bulk rna barcoding and sequencing

Interplay of the mechanical and structural properties of DNA nanostructures determines their electrostatic interactions with lipid membranes

Core-shell Structured Chitosan-polyethylenimine Nanoparticles for Gene Delivery: Improved Stability, Cellular Uptake, and Transfection Efficiency

Electronic and structural dynamics in DNA single strands

A simple micropreparative gel electrophoresis technique for purification of proteins, nucleic acids, and bioconjugates

Detecting DNA and RNA and Differentiating Single-Nucleotide Variations via Field-Effect Transistors

Regulation of cGAS- and RLR-mediated immunity to nucleic acids

Detecting topological variations of DNA at single-molecule level

Electronic Relaxation Dynamics of UV-Photoexcited 2-Aminopurine-Thymine Base Pairs in Watson-Crick and Hoogsteen Conformations

Graph Chatbot

Chattez avec Graph Search

Optimised set of oligonucleotides for bulk rna barcoding and sequencing

Landscapes of DNA Mechanics and Genomes

Interplay of the mechanical and structural properties of DNA nanostructures determines their electrostatic interactions with lipid membranes

Electronic Relaxation Dynamics of UV-Photoexcited 2-Aminopurine-Thymine Base Pairs in Watson-Crick and Hoogsteen Conformations

A simple micropreparative gel electrophoresis technique for purification of proteins, nucleic acids, and bioconjugates

Electronic and structural dynamics in DNA single strands

Detecting topological variations of DNA at single-molecule level

Detecting DNA and RNA and Differentiating Single-Nucleotide Variations via Field-Effect Transistors

Regulation of cGAS- and RLR-mediated immunity to nucleic acids

Core-shell Structured Chitosan-polyethylenimine Nanoparticles for Gene Delivery: Improved Stability, Cellular Uptake, and Transfection Efficiency