Concept

Valeur énergétique

Publications associées (32)

Investigating the metabolic changes due to visual stimulation using functional proton magnetic resonance spectroscopy at 7 T

Proton magnetic resonance spectroscopy ((1)H-MRS) has been used to demonstrate metabolic changes in the visual cortex on visual stimulation. Small (2% to 11%) but significant stimulation induced increases in lactate, glutamate, and glutathione were observe ...

2012

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

Pierre Magistretti, Igor Allaman

The energy requirements of the brain are very high, and tight regulatory mechanisms operate to ensure adequate spatial and temporal delivery of energy substrates in register with neuronal activity. Astrocytes a type of glial cell have emerged as active pla ...

2011

Extracting energy from a flow: An asymptotic approach using vortex-induced vibrations and feedback control

François Gallaire, Philippe Meliga

This paper considers vortex-induced vibrations of a cylinder in water streams for renewable energy production. We use an analytical model recently obtained by the authors from the asymptotic analysis of a coupled flow-cylinder system, and assess the abilit ...

2011

Brain energy metabolism and neurotransmission at near-freezing temperatures: In vivo 1H MRS study of a hibernating mammal

Rolf Gruetter

The brain of a hibernating mammal withstands physiological extremes that would result in cerebral damage and death in a non-hibernating species such as humans. To examine the possibility that this neuroprotection results from alterations in cerebral metabo ...

Wiley-Blackwell2007

Human brain glycogen content and metabolism: Implications on its role in brain energy metabolism

Rolf Gruetter, Ajay Kumar

The adult brain relies on glucose for its energy needs and stores it in the form of glycogen, primarily in astrocytes. Animal and culture studies indicate that brain glycogen may support neuronal function when the glucose supply from the blood is inadequat ...

2007

Effect of coenzyme Q10 and vitamin E on brain energy metabolism in the animal model of Huntington's disease

The neuropathological and clinical symptoms of Huntington's disease (HD) can be simulated in animal model with systemic administration of 3-nitropropionic acid (3-NP). Energy defects in HD could be ameliorated by administration of coenzyme Q10 (CoQ10), cre ...

2006

Brain lactate kinetics: Modeling evidence for neuronal lactate uptake upon activation

Pierre Magistretti, Luc Pellerin

A critical issue in brain energy metabolism is whether lactate produced within the brain by astrocytes is taken up and metabolized by neurons upon activation. Although there is ample evidence that neurons can efficiently use lactate as an energy substrate, ...

2005

Localized in vivo 13C NMR spectroscopy of the brain

Rolf Gruetter, Hongxia Lei

Localized (13)C NMR spectroscopy provides a new investigative tool for studying cerebral metabolism. The application of (13)C NMR spectroscopy to living intact humans and animals presents the investigator with a number of unique challenges. This review pro ...

Wiley-Blackwell2003

A2B receptor activation promotes glycogen synthesis in astrocytes through modulation of gene expression

Pierre Magistretti, Igor Allaman, Sylvain Eric Lengacher, Luc Pellerin

Adenosine has been proposed as a key factor regulating the metabolic balance between energy supply and demand in the central nervous system. Because astrocytes represent an important cellular element in the control of brain energy metabolism, we investigat ...

2002

Regulation of energy metabolism by neurotransmitters in astrocytes in primary culture and in an immortalized cell line

Pierre Magistretti, Jean-Luc Martin, Luc Pellerin

Evidence suggests that astrocytes might play an important role in cerebral energy metabolism. A recently developed cell line, called DI TNC1, displays several characteristic features of astrocytes. Thus, we have investigated in these cells a number of para ...

1997

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