Concept

Pompe sodium-potassium

Publications associées (35)

Coordination Numbers of K+ and Na+ Ions Inside the Selectivity Filter of the KcsA Potassium Channel: Insights from First Principles Molecular Dynamics

Ursula Röthlisberger, Denis Bucher, Paolo Carloni, Leonardo Guidoni

Quantum mechanics/molecular mechanics (QM/MM) Car-Parrinello simulations were performed to estimate the coordination numbers of K+ and Na+ ions in the selectivity filter of the KcsA channel, and in water. At the DFT/BLYP level, K+ ions were found to displa ...

Elsevier2010

Ensuring stability in models of atrial kinetics

Vincent Jacquemet

The membrane kinetics of human atrial myocytes as formulated by Courtemance, Ramierz and Nattel has been studied while focusing on its progression toward stationary solutions during long term repetitive stimulation. An algorithm is presented for finding th ...

2009

Potentiometric platform for the quantification of cellular potassium efflux

Nico de Rooij

Renewed interest in the measurement of cellular K+ effluxes has been prompted by the observation that potassium plays an active and important role in numerous key cellular events, in particular cell necrosis and apoptosis. Although necrosis and apoptosis f ...

2008

Functional interactions between anthrax toxin receptors and the WNT signalling protein LRP6

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Béatrice Kunz, Julie Deuquet Ariosa

To exert its activity, anthrax toxin must be endocytosed and its enzymatic toxic subunits delivered to the cytoplasm. It has been proposed that, in addition to the anthrax toxin receptors (ATRs), lipoprotein-receptor-related protein 6 (LRP6), known for its ...

2008

Regulation of the V-ATPase along the endocytic pathway occurs through reversible subunit association and membrane localization

Françoise Gisou van der Goot Grunberg, Céline Lafourcade

The lumen of endosomal organelles becomes increasingly acidic when going from the cell surface to lysosomes. Luminal pH thereby regulates important processes such as the release of internalized ligands from their receptor or the activation of lysosomal enz ...

Public Library of Science2008

Tools to study molecules in high electric fields

Denis Bucher

This thesis describes the application of the quantum mechanics/molecular mechanics (QM/MM) Car-Parrinello methodology to two systems of high biological interest: (a) The potassium channel KcsA from Streptomyces lividans and (b) The DNA repair enzyme EndoIV ...

EPFL2006

Relationship between L-glutamate-regulated intracellular Na+ dynamics and ATP hydrolysis in astrocytes

Pierre Magistretti, Jean-Yves Chatton

Glutamate uptake into astrocytes and the resulting increase in intracellular Na+ (Na+(i)) have been identified as a key signal coupling excitatory neuronal activity to increased glucose utilization. Arguments based mostly on mathematical modeling led to th ...

2004

Self-assembled organometallic receptors for small ions

Kay Severin

Trinuclear metallamacrocycles can be obtained by reactions of (arene)Ru, CpRh and CpIr complexes with pyridonate ligands. Using 3-oxy-pyridonate as the bridging ligand, organometallic analogues of 12-crown-3 are formed, which display an extremely high af ...

2003

Effects of glial glutamate transporter inhibitors on intracellular Na+ in mouse astrocytes

Pierre Magistretti, Jean-Yves Chatton

The effects of inhibitors of the glial Na+/glutamate co-transporter on the intracellular Na+ concentration (Na+) were investigated in mouse cortical astrocytes. Na+ was monitored by fluorescence microscopy on single astrocytes using the Na+-sensi ...

2001

Characterization of an encapsulation device for the production of monodisperse alginate beads for cell immobilization

Urs von Stockar, Ian William Marison, David Serp

An encapsulation device, designed on the basis of the laminar jet break-up technique, is characterized for cell immobilization with different types of alginate. The principle of operation of the completely sterilizable encapsulator, together with technique ...

2000

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