Concept

Pompe sodium-potassium

Publications associées (35)

Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity

Matteo Dal Peraro, Deniz Aydin, Xiao Guo

The UbiB protein kinase-like (PKL) family is widespread, comprising one-quarter of microbial PKLs and five human homologs, yet its biochemical activities remain obscure. COQ8A (ADCK3) is a mammalian UbiB protein associated with ubiquinone (CoQ) biosynthesi ...

Cell Press2016

alpha-Synuclein-induced dopaminergic neurodegeneration in a rat model of Parkinson's disease occurs independent of ATP13A2 (PARK9)

Bernard Schneider, Liliane Glauser, Elpida Tsika, Darren Moore, Alessandra Musso, Guillaume Daniel, Aris Nikolaos Fiser

Mutations in the ATP13A2 (PARK9) gene cause early-onset, autosomal recessive Parkinson's disease (PD) and Kufor-Rakeb syndrome. ATP13A2 mRNA is spliced into three distinct isoforms encoding a P5-type ATPase involved in regulating heavy metal transport acro ...

Academic Press Inc Elsevier Science2015

Light-Evoked Modulation of Neuronal Activity with Conjugated Polymers

Diego Ghezzi, Mattia Nova

Organic bioelectronics aims at the intimate integration between organic materials and biological tissues in order to obtain a targeted functional outcome. In the last decades, conductive polymers have been successfully employed to interface excitable cells ...

2015

Assessment of Pseudo-Bilayer Structures in the Heterogate Germanium Electron-Hole Bilayer Tunnel Field-Effect Transistor

Mihai Adrian Ionescu, Cem Alper, José Luis Padilla de la Torre

We investigate the effect of pseudo-bilayer configurations at low operating voltages (

American Institute of Physics2015

Learning-Induced Gene Expression in the Hippocampus Reveals a Role of Neuron-Astrocyte Metabolic Coupling in Long Term Memory

Pierre Magistretti, Igor Allaman, Gabriele Grenningloh, Sylvain Eric Lengacher, Monika Tadi

We examined the expression of genes related to brain energy metabolism and particularly those encoding glia (astrocyte)-specific functions in the dorsal hippocampus subsequent to learning. Context-dependent avoidance behavior was tested in mice using the s ...

Public Library of Science2015

Critical roles of isoleucine-364 and adjacent residues in a hydrophobic gate control of phospholipid transport by the mammalian P4-ATPase ATP8A2

Matteo Dal Peraro, Thomas Lemmin, Anna Vestergaard

P4-ATPases (flippases) translocate specific phospholipids such as phosphatidylserine from the exoplasmic leaflet of the cell membrane to the cytosolic leaflet, upholding an essential membrane asymmetry. The mechanism of flipping this giant substrate has re ...

Natl Acad Sciences2014

Na-ion dynamics in Quasi-1D compound NaV2O4

Martin Mansson

We have used the pulsed muon source at ISIS to study high-temperature Na-ion dynamics in the quasi-one-dimensional (Q1D) metallic antiferromagnet NaV2O4. By performing systematic zero-field and longitudinal-field measurements as a function of temperature w ...

Iop Publishing Ltd2014

A calcium ion-selective electrode array for monitoring the activity of HepG2/C3As in a microchannel

Philippe Renaud, Robert Meissner

Variations in calcium ion (Ca2+) concentrations play a crucial role in cell-cell communication; periodic changes act as cellular signals. In this study, we developed a solid-state calcium ion-selective electrode (Ca2+ ISE) integrated in a microchannel to m ...

Elsevier2012

Glutamate transport decreases mitochondrial pH and modulates oxidative metabolism in astrocytes

Hélène Danielle Perreten Lambert, Sylvain Eric Lengacher, Jean-Yves Chatton

During synaptic activity, the clearance of neuronally released glutamate leads to an intracellular sodium concentration increase in astrocytes that is associated with significant metabolic cost. The proximity of mitochondria at glutamate uptake sites in as ...

2011

A Potassium-Selective Quartz Crystal Microbalance Sensor Based on Crown-Ether Functionalized Polymer Brushes

Harm-Anton Klok, Nicolas Bertrand Schüwer

Benzo-15-crown-5 functionalized polymer brushes prepared via surface-initiated atom transfer radical polymerization are used as the active layer in a potassium-selective quartz crystal microbalance sensor. The polymer brushes allow the selective detection ...

Wiley-Blackwell2010

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