Concept
Carcinome lobulaire in situ
Publications associées (8)
Is There a Special Role for Ovarian Hormones in the Pathogenesis of Lobular Carcinoma?
Cathrin Brisken, Georgios Sflomos
Lobular carcinoma represent the most common special histological subtype of breast cancer, with the majority classed as hormone receptor positive. Rates of invasive lobular carcinoma in postmenopausal women have been seen to increase globally, while other ...
Endocrine Soc2024TGF beta-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progression
Cathrin Brisken, Andrea Agnoletto
Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer. Virtually all women with DCIS are treated, despite evidence suggesting up to half would remain with stable, non-threatening, disease. Overtreatment thus presents a press ...
NATURE PORTFOLIO2023Optimized Modeling of Metastatic Triple-Negative Invasive Lobular Breast Carcinoma
Cathrin Brisken, Georgios Sflomos, Laura Battista
Simple Summary Invasive lobular carcinoma (ILC) is the second most common histologic subtype of breast cancer and is often detected at an advanced stage. Up to 30% of ILC cases relapse and present a challenge for treatment. Unfortunately, there are few mod ...
MDPI2023Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1
Cathrin Brisken, Giovanna Ambrosini, Georgios Sflomos, Ayyakkannu Ayyanan, Laura Battista, Philipp Bucher, Maryse Fiche, Valentina Scabia, Patrik Aouad, Fabio De Martino
Invasive lobular carcinoma (ILC) is the most frequent special histological subtype of breast cancer, typically characterized by loss of E‐cadherin. It has clinical features distinct from other estrogen receptor‐positive (ER+) breast cancers but the molecul ...
2021Microfluidic staining technology and automated image processing for fast and accurate tissue-based diagnostics
The development of microfluidics has led to significant improvements in many areas of in vitro diagnostics. This thesis proposes the use of microfluidic device technology in the field of anatomic pathology, leading to faster and more accurate tissue-based ...
EPFL2016Functional consequences of prolactin signaling in endothelial cells: a potential link with angiogenesis in pathophysiology?
Prolactin is best known as the polypeptide anterior pituitary hormone, which regulates the development of the mammary gland. However, it became clear over the last decade that prolactin contributes to a broad range of pathologies, including breast cancer. ...
2012Selective Breast Cancer Cell Capture, Culture, and Immunocytochemical Analysis Using Self-Assembled Magnetic Bead Patterns in a Microfluidic Chip
Martinus Gijs, Jean-Claude Bünzli, Caroline Vandevyver, Venkataragavalu Sivagnanam, Bo Song
Separation and subsequent culturing of MCF-7 breast cancer cells on self-assembled protein-coated magnetic beads in a microfluidic chip is demonstrated. The beads were patterned in situ inside a sealed microfluidic channel using magnetic-field-assisted ele ...
American Chemical Society2010Regulation of human telomerase activity: repression by normal chromosome 3 abolishes nuclear telomerase reverse transcriptase transcripts but does not affect c-Myc activity
Telomerase is required for the complete replication of chromosomal ends. In tumors, the human telomerase reverse transcriptase subunit (hTERT) is up-regulated, thereby removing a critical barrier for unlimited cell proliferation. To understand more about h ...
2001