Publications associées à Acide γ-aminobutyrique

Glutamatergic and GABAergic energy metabolism measured in the rat brain by 13C NMR spectroscopy at 14.1 T

Rolf Gruetter, João Miguel das Neves Duarte

Energy metabolism supports both inhibitory and excitatory neurotransmission processes. This study investigated the specific contribution of astrocytic metabolism to γ-aminobutyric acid (GABA) synthesis and inhibitory GABAergic neurotransmission that remain ...

Wiley-Blackwell2013

An in vivo ultrahigh field 14.1 T (1) H-MRS study on 6-OHDA and α-synuclein-based rat models of Parkinson's disease: GABA as an early disease marker

Rolf Gruetter, Patrick Aebischer, Bernard Schneider, Philippe Guillaume Coune, Mélanie Craveiro, Meret Gaugler

The detection of Parkinson's disease (PD) in its preclinical stages prior to outright neurodegeneration is essential to the development of neuroprotective therapies and could reduce the number of misdiagnosed patients. However, early diagnosis is currently ...

Wiley-Blackwell2013

Synaptic Computation and Sensory Processing in Neocortical Layer 2/3

Carl Petersen, Sylvain Crochet

Computations in neocortical circuits are predominantly driven by synaptic integration of excitatory glutamatergic and inhibitory GABAergic inputs. New optical, electrophysiological, and genetic methods allow detailed in vivo investigation of the superficia ...

Cell Press2013

A Biophysically Detailed Model of Neocortical Local Field Potentials Predicts the Critical Role of Active Membrane Currents

Henry Markram, Sean Lewis Hill, Michael Reimann, Rodrigo de Campos Perin

Brain activity generates extracellular voltage fluctuations recorded as local field potentials (LFPs). It is known that the relevant microvariables, the ionic currents across membranes, jointly generate the macrovariables, the extracellular voltage, but ne ...

Elsevier2013

Hijacking the Neuronal NMDAR Signaling Circuit to Promote Tumor Growth and Invasion

Douglas Hanahan, Leanne Li

Glutamate and its receptor N-methyl-D-aspartate receptor (NMDAR) have been associated with cancer, although their functions are not fully understood. Herein, we implicate glutamate-driven NMDAR signaling in a mouse model of pancreatic neuroendocrine tumori ...

Cell Press2013

The allosteric communication pathways in KIX domain of CBP

Alessandro Barducci, Michele Parrinello

Allosteric regulation plays an important role in a myriad of bio-macromolecular processes. Specifically, in a protein, the process of allostery refers to the transmission of a local perturbation, such as ligand binding, to a distant site. Decades after the ...

National Academy of Sciences2013

Directed Evolution of Bicyclic Peptides for Therapeutic Application

Christian Heinis, Philippe Diderich

Many naturally occurring cyclic peptides or derivatives thereof are used as therapeutics such as the human hormones vasopressin and oxytocin or the antibiotics vancomycin and daptomycin. The success of cyclic peptide therapeutics is based on their ability ...

Schweizerische Chemische Gesellschaft2013

A randomised controlled trial of bumetanide in the treatment of autism in children

Nouchine Hadjikhani

Gamma aminobutyric acid (GABA)-mediated synapses and the oscillations they orchestrate are altered in autism. GABA-acting benzodiazepines exert in some patients with autism paradoxical effects, raising the possibility that like in epilepsies, GABA excites ...

Nature Publishing Group2012

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Acide γ-aminobutyrique

Glutamatergic and GABAergic energy metabolism measured in the rat brain by 13C NMR spectroscopy at 14.1 T

An in vivo ultrahigh field 14.1 T (1) H-MRS study on 6-OHDA and α-synuclein-based rat models of Parkinson's disease: GABA as an early disease marker

Synaptic Computation and Sensory Processing in Neocortical Layer 2/3

A Biophysically Detailed Model of Neocortical Local Field Potentials Predicts the Critical Role of Active Membrane Currents

Hijacking the Neuronal NMDAR Signaling Circuit to Promote Tumor Growth and Invasion

The allosteric communication pathways in KIX domain of CBP

Directed Evolution of Bicyclic Peptides for Therapeutic Application

Vesicular glutamate transporter-3 in the rodent brain: Vesicular colocalization with vesicular γ-aminobutyric acid transporter

A randomised controlled trial of bumetanide in the treatment of autism in children

SNAP-tag based FRET Indicator for GABA and Synthetic GABAB Receptor Ligands

Graph Chatbot

Chattez avec Graph Search

An in vivo ultrahigh field 14.1 T (1) H-MRS study on 6-OHDA and α-synuclein-based rat models of Parkinson's disease: GABA as an early disease marker

Glutamatergic and GABAergic energy metabolism measured in the rat brain by 13C NMR spectroscopy at 14.1 T

A Biophysically Detailed Model of Neocortical Local Field Potentials Predicts the Critical Role of Active Membrane Currents

Synaptic Computation and Sensory Processing in Neocortical Layer 2/3

SNAP-tag based FRET Indicator for GABA and Synthetic GABAB Receptor Ligands

A randomised controlled trial of bumetanide in the treatment of autism in children

Hijacking the Neuronal NMDAR Signaling Circuit to Promote Tumor Growth and Invasion

The allosteric communication pathways in KIX domain of CBP

Vesicular glutamate transporter-3 in the rodent brain: Vesicular colocalization with vesicular γ-aminobutyric acid transporter

Directed Evolution of Bicyclic Peptides for Therapeutic Application