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Handicap mental

Publications associées (74)

Modeling and Optimizing Computer-Assisted Mathematics Learning in Children

Arithmetic abilities are essential in modern society. However, many children suffer from difficulties in learning mathematics, ranging from mild to severe numeracy problems. The prevalence of developmental dyscalculia is about 3%−6% in German speaking coun ...

ETH-Zürich2013

Structural Variation-Associated Expression Changes Are Paralleled by Chromatin Architecture Modifications

Jacques Rougemont, Marion Leleu, Nele Gheldof

Copy number variants (CNVs) influence the expression of genes that map not only within the rearrangement, but also to its flanks. To assess the possible mechanism(s) underlying this "neighboring effect", we compared intrachromosomal interactions and histon ...

Public Library of Science2013

Social Inclusion: A Multidisciplinary Design Approach

This article shows the design of an assistive product and a proposal of a business plan for persons with motor disability in lower-limbs, in accordance with the guidelines for social inclusion of the World Health Organization (2001). The design project wit ...

2012

Towards a Framework for Modelling Engagement Dynamics in Multiple Learning Domains

In this paper, we explore the possibility of a general framework for modelling engagement dynamics in software tutoring, focusing on the cases of developmental dyslexia and developmental dyscalculia. This project aims at capturing the similar engagement st ...

2012

Hyperconnectivity and Slow Synapses during Early Development of Medial Prefrontal Cortex in a Mouse Model for Mental Retardation and Autism

Michele Giugliano

Neuronal theories of neurodevelopmental disorders (NDDs) of autism and mental retardation propose that abnormal connectivity underlies deficits in attentional processing. We tested this theory by studying unitary synaptic connections between layer 5 pyrami ...

Oxford University Press2012

Sparse reward processes

Christos Dimitrakakis

We introduce a class of learning problems where the agent is presented with a series of tasks. Intuitively, if there is a relation among those tasks, then the information gained during execution of one task has value for the execution of another task. Cons ...

arxiv2012

Evaluation of Proportional and Discrete Shared Control Paradigms for Low Resolution User Inputs

José del Rocio Millán Ruiz, Robert Leeb, Tom Edward Carlson, Guillaume Monnard

For people with severe physical disabilities, low resolution input devices, such as buttons, sip and puff switches and brain–computer interfaces provide an opportunity to interact with the world. However, it can be difficult to control assistive technology ...

IEEE2011

Epigenetic Modification of the FMR1 Gene in Fragile X Syndrome Is Associated with Differential Response to the mGluR5 Antagonist AFQ056

Nouchine Hadjikhani, Fei Chen

Fragile X syndrome (FXS) is an X-linked condition associated with intellectual disability and behavioral problems. It is caused by expansion of a CGG repeat in the 5' untranslated region of the fragile X mental retardation 1 (FMR1) gene. This mutation is a ...

2011

Assessment of Body Motion and Muscle Weakness

Raluca Lidia Ganea

Muscle weakness is a common symptom in elderly population and in children with Duchenne muscular dystrophy (DMD), causing impaired mobility. DMD is a devastating degenerative disease caused by a mutation in the dystrophin gene, leading to the absence of th ...

EPFL2011

Mercury is a direct and potent γ-secretase inhibitor affecting Notch processing and development in Drosophila

Bruno Lemaitre, Patrick Fraering, Mitko Dimitrov, Takayuki Kuraishi, Isabelle Chang

Prenatal exposure to mercury causes neurodevelopmental disorders and neurological pathologies in infants, such as microcephaly and mental retardation. Despite critical importance, the molecular interactions leading to mercury toxicity are yet to be elucida ...

2011

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