Publications associées à Lamarckisme

Variant-specific pathophysiological mechanisms of AFF3 differently influence transcriptome profiles

Giovanna Ambrosini, Nicolas Jean Philippe Guex, Christian Iseli

Background: We previously described the KINSSHIP syndrome, an autosomal dominant disorder associated with intellectual disability (ID), mesomelic dysplasia and horseshoe kidney,caused by de novo variants in the degron of AFF3. Mouse knock-ins and overexpre ...

BMC2024

Chronique des travaux en Égypte, chronique 2023

Aurélie Anne-Laure Terrier

Soutenus par l’Institut Français d’Archéologie Orientale du Caire, Ali Abdelhalim Ali (qui reprend les fonctions du professeur Shafia Bedier, décédée au mois de juin 2022), et Françoise Labrique ont codirigé en octobre 2022 une opération de terrain au temp ...

2023

Revoisiner. La dimension hospitalière du monde

Luca Giovanni Pattaroni

Parmi les questions aiguës posées par la crise climatique, étroitement liée à celle de l’accélération capitaliste1, on trouve celle, fondamentale, du lien que l’on tisse aux autres et au monde2. On peut avancer ainsi l’idée que de la double crise climatiqu ...

2022

Single-Cell Tracing Dissects Regulation of Maintenance and Inheritance of Transcriptional Reinduction Memory

Sebastian Maerkl, Johannes Becker

Transcriptional memory of gene expression enables adaptation to repeated stimuli across many organisms. However, the regulation and heritability of transcriptional memory in single cells and through divisions remains poorly understood. Here, we combined mi ...

2020

The Detection of Early Epigenetic Inheritance of Mitochondrial Stress in C. Elegans with a Microfluidic Phenotyping Platform

Johan Auwerx, Martinus Gijs, Matteo Cornaglia, Hüseyin Baris Atakan

Fluctuations and deterioration in environmental conditions potentially have a phenotypic impact that extends over generations. Transgenerational epigenetics is the defined term for such intergenerational transient inheritance without an alteration in the D ...

Nature Research2019

Des pratiques et représentations genrées de la voiture chez les adolescents : Le cas européen

Vincent Kaufmann, Emmanuel Pierre Jean Ravalet, Guillaume Simon Joseph Drevon

L'adolescence est souvent considérée dans les politiques de transports comme une période de transition entre dépendance aux parents et autonomie complète à l'âge adulte. Mieux connaître les représentations sociales associées aux modes de transport, et en p ...

2019

Mitochondrial unfolded protein response, its molecular mechanism and physiological impact

Virginija Jovaisaite

Mitochondria are the main producers of ATP, the energy currency of the cell, and they perform a wide array of other fundamental functions. These organelles are essential not only for cellular metabolism, but also for organismal physiology and lifespan. A r ...

EPFL2016

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

Johan Auwerx, Laurent Mouchiroud, Evan Graehl Williams, Virginija Jovaisaite

Across eukaryotic species, mild mitochondrial stress can have beneficial effects on the lifespan of organisms. Mitochondrial dysfunction activates an unfolded protein response (UPR(mt)), a stress signaling mechanism designed to ensure mitochondrial homeost ...

Cell Press2016

Optimization of Conformational Dynamics in an Epistatic Evolutionary Trajectory

Luciano Andres Abriata

The understanding of protein evolution depends on the ability to relate the impact of mutations on molecular traits to organismal fitness. Biological activity and robustness have been regarded as important features in shaping protein evolutionary landscape ...

Oxford Univ Press2016

RECURRENT AND RECENT SELECTIVE SWEEPS IN THE piRNA PATHWAY

Jeffrey David Jensen

Uncontrolled transposable element (TE) insertions and excisions can cause chromosome breaks and mutations with dramatic deleterious effects. The PIWI interacting RNA (piRNA) pathway functions as an adaptive TE silencing system during germline development. ...

Wiley-Blackwell2013