Concept

British Library

Publications associées (39)

Design of an artificial phage-display library based on a new scaffold improved for average stability of the randomized proteins

Scaffold-based protein libraries are designed to be both diverse and rich in functional/folded proteins. However, introducing an extended diversity while preserving stability of the initial scaffold remains a challenge. Here we developed an original approa ...

NATURE PORTFOLIO2023

Genetic Algorithms for the Discovery of Homogeneous Catalysts

Rubén Laplaza Solanas, Anne-Clémence Corminboeuf, Puck Elisabeth van Gerwen, Alexandre Alain Schöpfer, Simone Gallarati

In this account, we discuss the use of genetic algorithms in the inverse design process of homogeneous catalysts for chemical transformations. We describe the main components of evolutionary experiments, specifically the nature of the fitness function to o ...

2023

Technology Mapping Using Multi-output Library Cells

Giovanni De Micheli, Alessandro Tempia Calvino

Technology mapping transforms a technology-independent representation into a technology-dependent one given a library of cells. Even if technology libraries contain multi-output cells, state-of-the-art techniques fully exploit single-output cells only. Mul ...

2023

PMT: Power Measurement Toolkit

Stefano Corda

Efficient use of energy is essential for today's supercomputing systems, as energy cost is generally a major component of their operational cost. Research into "green computing" is needed to reduce the environmental impact of running these systems. As such ...

IEEE COMPUTER SOC2022

De novo developed small cyclic peptides that are orally available

Manuel Leonardo Merz

Cyclic peptides are ring-shaped molecules that emerged as a promising class of therapeutics. While it is often difficult to find small molecule binders for challenging disease targets, cyclic peptides can bind to featureless surfaces or inhibit protein-pro ...

EPFL2022

Generating macrocyclic inhibitors of protein-protein interactions

Gontran Sangouard

Protein-protein interactions (PPIs) play important roles in many diseases and their modulation is an attractive strategy for developing new therapeutics. However, the relatively large and often flat binding surfaces of PPIs makes the development of inhibit ...

EPFL2022

Methods for the generation of large combinatorial macrocycle libraries

Sevan Mleh Habeshian

Macrocycles are an attractive class of molecules due to their good binding properties and yet rather small size that allows, in many cases, crossing membranes to reach intracellular targets. In comparison to classical small molecule drugs, macrocycles are ...

EPFL2021

Too Quiet in the Library: An Empirical Study of Security Updates in Android Apps' Native Code

Mathias Josef Payer

Android apps include third-party native libraries to increase performance and to reuse functionality. Native code is directly executed from apps through the Java Native Interface or the Android Native Development Kit. Android developers add precompiled nat ...

IEEE COMPUTER SOC2021

Tamaas: a library for elastic-plastic contact of periodic rough surfaces

Jean-François Molinari, Guillaume Anciaux, Son-Jonathan Pham-Ba, Lucas Henri Galilée Frérot, Valentine Ginette Madeleine Rey

Tamaas: a library for elastic-plastic contact of periodic rough surfaces", published in the Journal of Open Source Softwares describes the free and open-source library Tamaas. More than five years in the making, Tamaas is a high performance C++/Python libr ...

2020

Real-Time Dance Generation to Music for a Legged Robot

Marco Hutter

The development of robots that can dance has received considerable attention. However, they are often either limited to a pre-defined set of movements and music or demonstrate little variance when reacting to external stimuli, such as microphone or camera ...

2019

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