Concept
Inner nuclear membrane protein
Publications associées (30)
Computer simulations reveal mechanisms that organize nuclear dynein forces to separate centrosomes
Pierre Gönczy, Alessandro De Simone
Centrosome separation along the surface of the nucleus at the onset of mitosis is critical for bipolar spindle assembly. Dynein anchored on the nuclear envelope is known to be important for centrosome separation, but it is unclear how nuclear dynein forces ...
Amer Soc Cell Biology2017Dynein Transmits Polarized Actomyosin Cortical Flows to Promote Centrosome Separation
Pierre Gönczy, Alessandro De Simone
The two centrosomes present at the onset of mitosis must separate in a timely and accurate fashion to ensure proper bipolar spindle assembly. The minus-end-directed motor dynein plays a pivotal role in centrosome separation, but the underlying mechanisms r ...
Elsevier2016Mechanisms of centrosome separation in C. elegans
Centrosomes are the major microtubule organizing centers of animal cells. The two centrosomes present at the onset of mitosis must separate in a timely fashion along the nuclear envelope to ensure proper bipolar spindle assembly and thus genome stability. ...
EPFL2016Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration
Graham Knott, Liliane Glauser, Elpida Tsika, Darren Moore, Shi-Yan Caroline Foo, Meghna Kannan
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant Parkinson's disease (PD). The clinical and neurochemical features of LRRK2-linked PD are similar to idiopathic disease although neuropathology is somewhat heter ...
Elsevier2014Selective transport control on molecular velcro made from intrinsically disordered proteins
The selectivity and speed of many biological transport processes(1) transpire from a 'reduction of dimensionality'(2) that confines diffusion to one or two dimensions instead of three(3). This behaviour remains highly sought after on polymeric surfaces(4) ...
Nature Publishing Group2014The nucleoporin Nup205/NPP-3 is lost near centrosomes at mitotic onset and can modulate the timing of this process in Caenorhabditis elegans embryos
Regulation of mitosis in time and space is critical for proper cell division. We conducted an RNA interference-based modifier screen to identify novel regulators of mitosis in Caenorhabditis elegans embryos. Of particular interest, this screen revealed tha ...
Amer Soc Cell Biology2012The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast
Budding yeast telomeres are reversibly bound at the nuclear envelope through two partially redundant pathways that involve the Sir2/3/4 silencing complex and the Yku70/80 heterodimer(1,2). To better understand how this is regulated, we studied the role of ...
2011Intrinsic differences between the catalytic properties of the oncogenic NUP214-ABL1 and BCR-ABL1 fusion protein kinases
The NUP214-ABL1 fusion kinase has recently been identified in 6% of patients with T-cell acute lymphoblastic leukemia. In contrast to the more common oncogenic ABL1 fusion BCR-ABL1, NUP214-ABL1 localizes to the nuclear pore complexes and has attenuated tra ...
Nature Publishing Group2008Transcription and chromatin organization of a housekeeping gene cluster containing an integrated beta-globin locus control region
The activity of locus control regions (LCR) has been correlated with chromatin decondensation, spreading of active chromatin marks, locus repositioning away from its chromosome territory (CT), increased association with transcription factories, and long-ra ...
Public Library of Science2008Automatic Tracking of Individual Fluorescence Particles: Application to the Study of Chromosome Dynamics
We present a new, robust, computational procedure for tracking fluorescent markers in time-lapse microscopy. The algorithm is optimized for finding the time-trajectory of single particles in very noisy dynamic (two- or three-dimensional) image sequences. I ...
IEEE2005