Publications associées à Récepteur du facteur de croissance épidermique

The Multi-kinase Inhibitor Debio 0617B Reduces Maintenance and Self-renewal of Primary Human AML CD34(+) Stem/Progenitor Cells

Michel Aguet, Stefania Rigotti, Maximilien Murone, Andres McAllister

Acute myelogenous leukemia (AML) is initiated and maintained by leukemia stem cells (LSC). LSCs are therapy-resistant, cause relapse, and represent a major obstacle for the cure of AML. Resistance to therapy is often mediated by aberrant tyrosine kinase (T ...

Amer Assoc Cancer Research2017

Paracrine Activin-A Signaling Promotes Melanoma Growth and Metastasis through Immune Evasion

Daniel Constam, Susanna Eveliina Kallioinen, Olivier Andreas Dubey, Patrick Mueller

The secreted growth factor Activin-A of the transforming growth factor beta family and its receptors can promote or inhibit several cancer hallmarks including tumor cell proliferation and differentiation, vascularization, lymphangiogenesis and inflammation ...

2017

In vivo reprogramming of non-mammary cells to an epithelial cell fate is independent of amphiregulin signaling

Cathrin Brisken, Stéphanie Cagnet

AREG-/- mice demonstrate impaired mammary development and form only rudimentary ductal epithelial trees, however, AREG-/- glands are still capable of undergoing alveologenesis and lactogenesis during pregnancy. Transplantation of AREG-/- mammary epithelial ...

Company of Biologists2017

Debio 0617B Inhibits Growth of STAT3-Driven Solid Tumors through Combined Inhibition of JAK, SRC, and Class III/V Receptor Tyrosine Kinases

Michel Aguet, Stefania Rigotti, Maximilien Murone, Andres McAllister, Olivier Michielin

Tumor survival, metastases, chemoresistance, and escape from immune responses have been associated with inappropriate activation of STAT3 and/or STAT5 in various cancers, including solid tumors. Debio 0617B has been developed as a first-in-class kinase inh ...

Amer Assoc Cancer Research2016

SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150

Paloma Ordonez Moran

SPROUTY-2 (SPRY2) is a modulator of tyrosine kinase receptor signaling with receptor-and cell type-dependent inhibitory or enhancing effects. Studies on the action of SPRY2 in major cancers are conflicting and its role remains unclear. Here we have dissect ...

Nature Publishing Group2016

Oral transfer of chemical cues, growth proteins and hormones in social insects

Laure Menin, Oksana Riba Grognuz, Laurent Keller

Social insects frequently engage in oral fluid exchange trophallaxis between adults, and between adults and larvae. Although trophallaxis is widely considered a food-sharing mechanism, we hypothesized that endogenous components of this fluid might underlie ...

Elife Sciences Publications Ltd2016

Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction

Freddy Radtke, Matthias Lütolf, Georg Fantner, Yann Barrandon, Sylke Höhnel, Pascal Damian Odermatt, Craig Nowell, Luca Azzolin

Chronic inflammation is associated with a variety of pathological conditions in epithelial tissues, including cancer, metaplasia and aberrant wound healing. In relation to this, a significant body of evidence suggests that aberration of epithelial stem and ...

Nature Publishing Group2016

Dynamic nuclear polarization at 40 kHz magic angle spinning

David Lyndon Emsley, Moreno Lelli, Pierrick Berruyer, David Benjamin Roger Antoine Gajan

DNP-enhanced solid-state NMR spectroscopy under magic angle spinning (MAS) is rapidly developing into a powerful analytical tool to investigate the structure of a wide range of solid materials, because it provides unsurpassed sensitivity gains. Most develo ...

Royal Society of Chemistry2016

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Récepteur du facteur de croissance épidermique

The Multi-kinase Inhibitor Debio 0617B Reduces Maintenance and Self-renewal of Primary Human AML CD34(+) Stem/Progenitor Cells

Paracrine Activin-A Signaling Promotes Melanoma Growth and Metastasis through Immune Evasion

In vivo reprogramming of non-mammary cells to an epithelial cell fate is independent of amphiregulin signaling

Debio 0617B Inhibits Growth of STAT3-Driven Solid Tumors through Combined Inhibition of JAK, SRC, and Class III/V Receptor Tyrosine Kinases

From the early steps of whisker formation to its evolutionary disappearance: the (curious) case of Prdm1 and its regulation

A balancing act between stratification and EMT in cultured human thymic epithelial cells

SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150

Oral transfer of chemical cues, growth proteins and hormones in social insects

Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction

Dynamic nuclear polarization at 40 kHz magic angle spinning

Graph Chatbot

Chattez avec Graph Search

SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150

Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction

The Multi-kinase Inhibitor Debio 0617B Reduces Maintenance and Self-renewal of Primary Human AML CD34(+) Stem/Progenitor Cells

Paracrine Activin-A Signaling Promotes Melanoma Growth and Metastasis through Immune Evasion

In vivo reprogramming of non-mammary cells to an epithelial cell fate is independent of amphiregulin signaling

Debio 0617B Inhibits Growth of STAT3-Driven Solid Tumors through Combined Inhibition of JAK, SRC, and Class III/V Receptor Tyrosine Kinases

A balancing act between stratification and EMT in cultured human thymic epithelial cells

From the early steps of whisker formation to its evolutionary disappearance: the (curious) case of Prdm1 and its regulation

Dynamic nuclear polarization at 40 kHz magic angle spinning

Oral transfer of chemical cues, growth proteins and hormones in social insects