Concept

Encéphalopathie spongiforme bovine

Publications associées (22)

Silolothiophene-linked triphenylamines as stable hole transporting materials for high efficiency perovskite solar cells

Michael Graetzel, Mohammad Khaja Nazeeruddin, Shaik Mohammed Zakeeruddin, Fabrizio Giordano, Ulf Anders Hagfeldt, Peng Gao, Michael Saliba, Sanghyun Paek, Antonio Abate, Juan-Pablo Correa-Baena, Taisuke Matsui

In this work, we synthesized novel hole transporting materials (HTMs) and studied their impact on the stability of perovskite-based solar cells (PSCs). The steady-state maximum power output of devices in working condition was monitored to assess the stabil ...

Royal Society of Chemistry2015

Specificity and Regulation of the Endoplasmic Reticulum-Associated Degradation Machinery

Maurizio Molinari

The endoplasmic reticulum-associated degradation (ERAD) machinery selects native and misfolded polypeptides for dislocation across the ER membrane and proteasomal degradation. Regulated degradation of native proteins is an important aspect of cell physiolo ...

Wiley-Blackwell2013

Understanding amyloid aggregation by statistical analysis of atomic force microscopy images

Giovanni Dietler, Paolo De Los Rios, Jérôme Flakowski, Raffaele Mezzenga

The aggregation of proteins is central to many aspects of daily life, including food processing, blood coagulation, eye cataract formation disease and prion-related neurodegenerative infections[1–5]. However, the physical mechanisms responsible for amyloid ...

Nature Publishing Group2010

Solute energy based REMD

Molecular dynamics (MD) simulations have increasingly contributed to the understanding of biomolecular processes, allowing for predictions of thermodynamic and structural properties. Unfortunately, the holy grail of protein structure prediction was soon fo ...

EPFL2008

Antiprion prophylaxis by gene transfer of a soluble prion antagonist

Didier Trono

Prion diseases are untreatable neurodegenerative disorders characterized by accumulation of PrP(Sc), an aggregated isoform of the normal prion protein PrP(C). Here, we delivered the soluble prion antagonist PrP-Fc(2) to the brains of mice by lentiviral gen ...

American Society for Investigative Pathology2008

The materials science of protein aggregation

Hilal Lashuel

Numerous human diseases are associated with conformational change and aggregation of proteins, including Alzheimer's, Parkinson's, prion diseases (such as mad cow disease), familial amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease), Huntington's ...

Materials Research Society2005

A new evolutionary scenario for the Mycobacterium tuberculosis complex

Stewart Cole

The distribution of 20 variable regions resulting from insertion-deletion events in the genomes of the tubercle bacilli has been evaluated in a total of 100 strains of Mycobacterium tuberculosis, Mycobacterium africanum, Mycobacterium canettii, Mycobacteri ...

2002

PrP-deficient mice are resistant to scrapie

Michel Aguet

Prusiner proposed that the infectious agent of scrapie, the prion, is PrPSc, a modified form of the normal host protein PrPC. Prn-p0/0 mice devoid of PrPC showed normal development and behavior. When inoculated with mouse scrapie prions they remained free ...

1994

Susceptibility to Scrapie in Mice Is Dependent on Prpc

Michel Aguet

Mice devoid of functional PrP genes (Prn-p(0/0) mice) showed normal development and behaviour. When inoculated with mouse scrapie prions they remained free of scrapie symptoms for at least 18 months whereas wild-type controls all died within 6 months. No p ...

1994

Role of the Prp Gene in Transmissible Spongiform Encephalopathies

Michel Aguet

The transmissible agent that causes spongiform encephalopathies such as scrapie, the prion, is believed to be devoid of nucleic acid and identical with PrP(Sc), a modified form of PrP(C). PrP(C) is a normal host protein encoded by a single copy gene (Prn-p ...

1993

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