Concept

Parainfluenza

Publications associées (56)

Multi-resistance of human enterovirus to UV-C disinfection and mutagenic nucleoside analogs

Tamar Kohn, Anna Carratala Ripolles, Virginie Bachmann, Qingxia Zhong

Disinfection is an important strategy to control the environmental transmission of human viruses. Specifically, UV254 is increasingly used to disinfect from clinical items or surfaces to drinking water. RNA virus populations have high mutation rates and la ...

2016

Viral RNA Degradation and Diffusion Act as a Bottleneck for the Influenza A Virus Infection Efficiency

Christian Sieben

After endocytic uptake, influenza viruses transit early endosomal compartments and eventually reach late endosomes. There, the viral glycoprotein hemagglutinin (HA) triggers fusion between endosomal and viral membrane, a critical step that leads to release ...

Public Library Science2016

Viruses at solid-water interfaces: A systematic assessment of interactions driving adsorption

Tamar Kohn, Meret Aeppli, Anne Thérèse Sigstam, Antonius Magdi Hakeem Armanious, Dominik Refardt

Adsorption to solid-water interfaces is a major process governing the fate of waterborne viruses in natural and engineered systems. The relative contributions of different interaction forces to adsorption and their dependence on the physicochemical propert ...

Amer Chemical Soc2016

Influence of Temperature, VFA and pH on the inactivation of pathogens in anaerobic digestion of faecel sludge

Livia Jost

On-site sanitation technologies such as septic tanks are widely used in low- and middle-income countries. A comprehensive management of the accumulating faecal sludge (FS) is however missing in most contexts and uncontrolled disposal of FS results in serio ...

2015

Principal parameters affecting virus inactivation by the solar photo-Fenton process at neutral pH and mu M concentrations of H2O2 and Fe2+/(3+)

César Pulgarin, Anna Carratala Ripolles

The inactivation of the coliphage MS2 (a human virus indicator) by solar photo-Fenton at near neutral pH in carbonate buffer solution matrix was evaluated. The effects of reactant concentration (H2O2, Fe2+, Fe3+) and solar irradiance on the photo-Fenton pr ...

2015

Evolution of the Influenza A Virus Genome during Development of Oseltamivir Resistance In Vitro

Jeffrey David Jensen

Influenza A virus (IAV) is a major cause of morbidity and mortality throughout the world. Current antiviral therapies include oseltamivir, a neuraminidase inhibitor that prevents the release of nascent viral particles from infected cells. However, the IAV ...

Amer Soc Microbiology2014

Subtle differences in virus composition affect disinfection kinetics and mechanisms

Tamar Kohn, Krista Rule Wigginton, Brian Pecson, Michele Cascella, Anne Thérèse Sigstam

Viral disinfection kinetics have been studied in depth, but the molecular-level inactivation mechanisms are not understood. Consequently, it is difficult to predict the disinfection behavior of non-culturable viruses, even when related, culturable viruses ...

American Society for Microbiology2013

Mechanisms of Human Adenovirus Inactivation by Sunlight and UVC Light as Examined by Quantitative PCR and Quantitative Proteomics

Tamar Kohn, Romain Hamelin, Florence Armand, Franziska Sara Bosshard

Human adenoviruses (HAdV) are important pathogens in both industrialized and developing nations. HAdV has been shown to be relatively resistant to monochromatic UVC. Polychromatic UVC, in contrast, is a more effective means of disinfection, presumably due ...

American Society for Microbiology2013

Virus Inactivation by Homogeneous and Heterogeneous Fenton-like Processes

Jessica Ivana Nieto Juarez

Human enteric viruses in water sources cause a great public health risk. Conventional disinfection treatments are not able to completely inactive viruses. However, advanced oxidation processes (AOPs) have recently been shown to effectively inactivate patho ...

EPFL2012

Down-regulation of phosphatase and tensin homolog by hepatitis C virus core 3a in hepatocytes triggers the formation of large lipid droplets

David Michael Suter

Hepatitis C virus (HCV) perturbs the host's lipid metabolism and often results in hepatic steatosis. In nonalcoholic fatty liver disease, the intrahepatic down-regulation of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a critical mecha ...

2011

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