Concept
Jeûne intermittent
Publications associées (34)
Common Mechanisms for Calorie Restriction and AC5 Knockout Models of Longevity
Adenylyl cyclase type 5 knockout mice (AC5 KO) live longer and are stress resistant, similar to calorie restriction (CR). AC5 KO mice eat more, but actually weigh less and accumulate less fat compared to WT mice. CR applied to AC5 KO result in rapid decrea ...
Wiley-Blackwell2012Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans
Johan Auwerx, Richardus Houtkooper, Dongryeol Ryu
Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we treated 11 healthy, obese men with placebo and 150 mg/day resveratrol (r ...
2011Calorie restriction: is AMPK a key sensor and effector?
Johan Auwerx, Carlos Canto Alvarez
Dietary restriction can extend life span in most organisms tested to date, suggesting that mechanisms sensing nutrient and energy availability might regulate longevity. The AMP-activated protein kinase (AMPK) has emerged as a key energy sensor with the abi ...
2011CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability
Johan Auwerx, Carlos Canto Alvarez, Chikage Mataki, Hiroyasu Yamamoto, Lilia Noriega Lopez, Jiujiu Yu
The nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase SIRT1 is a major metabolic regulator activated by energy stresses such as fasting or calorie restriction. SIRT1 activation during fasting not only relies on the increase in the NAD(+)/NAD ...
2011SIRT1 mRNA Expression May Be Associated with Energy Expenditure and Insulin Sensitivity
Johan Auwerx, Hiroyasu Yamamoto
Objective - Sirtuin 1 (SIRT1) is implicated in the regulation of mitochondrial function, energy metabolism, and insulin sensitivity in rodents. No studies are available in humans to demonstrate that SIRT1 expression in insulin sensitive tissues is associat ...
2010Serum Bile Acids Are Higher in Humans With Prior Gastric Bypass: Potential Contribution to Improved Glucose and Lipid Metabolism
The multifactorial mechanisms promoting weight loss and improved metabolism following Roux-en-Y gastric bypass (GB) surgery remain incompletely understood. Recent rodent studies suggest that bile acids can mediate energy homeostasis by activating the G-pro ...
2009The Importance of Viscoplastic Strain Rate in the Formation of Center Cracks during the Start-Up Phase of Direct-Chill Cast Aluminum Extrusion Ingots
A comparison of experimental observations and computer simulations shows that trends in the occurrence and severity of center cracks in direct-chill (DC) cast ingots due to different initial casting speed histories may best be explained by the changes in v ...
2003