Concept
Cellule somatique
Publications associées (59)
Deciphering the molecular events leading to the global restoration of the chromatin landscape during mitotic exit
Two fundamental properties of embryonic stem cells (ESCs) are their ability to self-renew and differentiate into all somatic cell types. Maintenance of their identity faces major challenges when transitioning through mitosis, as most DNA-binding proteins a ...
EPFL2023RUM: Reconfigurable Umbrella Mesh
Mark Pauly, Florin Isvoranu, Uday Kusupati, Seiichi Eduardo Suzuki Erazo
We propose Reconfigurable Umbrella Meshes (RUMs), a new class of preassembled deployable structures. A RUM has a compact rest state that can be easily altered to deploy into different bending-active 3D target shapes. RUMs consist of elastic beams and rigid ...
De Gruyter2023Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections
Didier Trono, Julien Paul André Pontis, Yu Tao
The transcription factor network required for primordial germ cell (PGC) specification is known to diverge in mammals. Here the authors show that hominidae-specific transposable element (TE) LTR5Hs becomes transcriptionally active during PGC specification, ...
NATURE PORTFOLIO2022Deep Learning Enables Individual Xenograft Cell Classification in Histological Images by Analysis of Contextual Features
Michaël Unser, Cathrin Brisken, Daniel Sage, Olivier Burri, Martin Weigert, Fabio De Martino, Quentin Juppet
Patient-Derived Xenografts (PDXs) are the preclinical models which best recapitulate inter- and intra-patient complexity of human breast malignancies, and are also emerging as useful tools to study the normal breast epithelium. However, data analysis gener ...
2021Apparatus and method for locating cells generating an electrical anomaly in a subject's body part
The present invention concerns a data processing apparatus for locating source cells (25) responsible for an electrical anomaly in a subject's body part (8). The apparatus comprises means for: obtaining one or more electrical signals (19) resulting from el ...
2021Characterization of the ERK1/2 phosphorylation profile in human and fish liver cells upon exposure to chemicals of environmental concern
Kristin Schirmer, Jelena Petrovic
We developed phospho-ERK1/2 ELISA for human and rainbow trout liver cells, employing HepG2 and RTL-W1 cell lines as models. The assay was applied to detect changes in ERK1/2 activity for nine chemicals, added over a wide concentration range and time points ...
ELSEVIER2021Comparative Transcriptomics Analyses across Species, Organs, and Developmental Stages Reveal Functionally Constrained lncRNAs
Fabrice Daniel Darbellay, Anamaria Necsulea
The functionality of long noncoding RNAs (lncRNAs) is disputed. In general, lncRNAs are under weak selective pressures, suggesting that the majority of lncRNAs may be nonfunctional. However, although some surveys showed negligible phenotypic effects upon l ...
OXFORD UNIV PRESS2020A single-cell-based identification and characterisation of Aregs, an inhibitory subpopulation of adipose stem and precursor cells
Adipose tissue is an essential element in energy conservation mechanisms. Its unique plasticity is driven by the ability of adipocytes to accumulate and liberate lipids as a function of the energetic status of the organism. Given the recent rise in the glo ...
EPFL2020Tracing of Human Tumor Cell Lineages by Mitochondrial Mutations
Stephan Morgenthaler, Paul Refinetti, Per Olaf Ekstrom
Background Previous studies have shown the value in studying lineage tracing in slices of human tumors. However, a tumor is not a two-dimensional structure and to better understand how a tumor, and its corresponding metastasis grow, a three-dimensional (3- ...
FRONTIERS MEDIA SA2020A Single Metabolite which Modulates Lipid Metabolism Alters Hematopoietic Stem/Progenitor Cell Behavior and Promotes Lymphoid Reconstitution
Matthias Lütolf, Sonja Giger, Marlen Knobloch, Mergim Ramosaj
Fatty acid beta-oxidation (FAO), the breakdown of lipids, is a metabolic pathway used by various stem cells. FAO levels are generally high during quiescence and downregulated with proliferation. The endogenous metabolite malonyl-CoA modulates lipid metabol ...
2020