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Limitations and Uncertainties of Acute Fish Toxicity Assessments Can Be Reduced Using Alternative Methods

Kristin Schirmer

Information about acute fish toxicity is routinely required in many jurisdictions for environmental risk assessment of chemicals. This information is typically obtained using a 96-hour juvenile fish test for lethality according to OECD test guideline (TG) ...

2021

Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): rationale and study design

Ileana Ozana Jelescu

Background Subjective cognitive decline (SCD) is the subjective perception of a decline in memory and/or other cognitive functions in the absence of objective evidence. Some SCD individuals however may suffer from very early stages of neurodegenerative dis ...

2021

Risk-based methodology to assess bridge condition based on visual inspection

Eugen Brühwiler, Numa Joy Bertola

The visual inspection of existing infrastructure is a critical step for asset management, as the detection and quantification of damage must be useful to prioritise maintenance. In Switzerland, main inspections are made every five years for all road bridge ...

2021

EaRL: An Open-Source Software for Earthquake Risk, Loss and Lifecycle Assessment

Dimitrios Lignos, Ahmed Mohamed Ahmed Elkady

Evaluating earthquake-induced losses, such as structural repair costs, downtime and casualties, is becoming a standard practice within the performance-based earthquake engineering framework. Nonetheless, this evaluation is a demanding task that requires de ...

2021

In Vitro Digestion of Tire Particles in a Fish Model (Oncorhynchus mykiss): Solubilization Kinetics of Heavy Metals and Effects of Food Coingestion

Kristin Schirmer, Florian Frédéric Vincent Breider, Benoît Jean Dominique Ferrari, Thibault Béranger Masset

Tire and road wear particles (TRWP) have been shown to represent a large part of anthropogenic particles released into the environment. Nevertheless, the potential ecological risk of TRWP in the different environmental compartments and their potential toxi ...

2021

Innovative Techniques and Strategies for a Reliable High-Throughput Genotoxicity Assessment

Pauline Franz

Damage to DNA is a central mechanism to the initiation of carcinogenesis. As a consequence, precise DNA damage detection is essential for an effective risk assessment of xenobiotics and constitutes a powerful tool for human biomonitoring and early stage ca ...

AMER CHEMICAL SOC2020

A risk-based multi-level stress test methodology: application to six critical non-nuclear infrastructures in Europe

Anton Schleiss, José Pedro Gamito de Saldanha Calado Matos, Daniela Rodrigues

Recent natural disasters that seriously affected critical infrastructure (CI) with significant socio-economic losses and impact revealed the need for the development of reliable methodologies for vulnerability and risk assessment. In this paper, a risk-bas ...

2020

Assessing Subaquatic Mass Movement Hazards: an Integrated Observational and Hydrodynamic Modelling Approach

Alfred Johny Wüest, Damien Bouffard, Nathalie Dubois, Carl Love Mikael Råman Vinnå

High-resolution lake and reservoir bathymetric surveys can pinpoint locations that may experience underwater landslides (subaquatic sedimentary mass movements). These can pose a risk to underwater and shoreline infrastructure. This paper outlines an approa ...

2020

Impact of facade details on the reliability of performance-based decisions for early-stage neighborhood designs

Minu Agarwal

Neighborhood-scale projects often commence with the conceptualization of several massing-schemes as potential design solutions. There is growing interest in using building performance simulation (BPS) to evaluate and rank such conceptual stage schemes in o ...

EPFL2020

Extending the Concept of Predicting Fish Acute Toxicity In Vitro to the Intestinal Cell Line RTgutGC

Kristin Schirmer, Hannah Inka Schug, Jenny Maner

Testing chemicals for fish acute toxicity is a legal requirement in many countries as part of environmental risk assessment. To reduce the number of fish used, substantial efforts have been focused on alternative approaches. Prominently, the cell viability ...

2020

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Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): rationale and study design

Ileana Ozana Jelescu

2021

EaRL: An Open-Source Software for Earthquake Risk, Loss and Lifecycle Assessment

Dimitrios Lignos, Ahmed Mohamed Ahmed Elkady

2021

In Vitro Digestion of Tire Particles in a Fish Model (Oncorhynchus mykiss): Solubilization Kinetics of Heavy Metals and Effects of Food Coingestion

Kristin Schirmer, Florian Frédéric Vincent Breider, Benoît Jean Dominique Ferrari, Thibault Béranger Masset

2021