Concept

Arborisation terminale

Publications associées (132)

Vesicular glutamate transporter-3 in the rodent brain: Vesicular colocalization with vesicular γ-aminobutyric acid transporter

Vesicular glutamate transporters (VGLUT1–3) carry glutamate into synaptic vesicles. VGLUT3 has been reported to be localized in nonglutamatergic neuronal populations in the brain. However, detailed subcellular localization of VGLUT3 has not been shown. In ...

2013

Matched Pre- and Post-Synaptic Changes Underlie Synaptic Plasticity over Long Time Scales

Henry Markram, Jean-Vincent Le Bé

Modifications of synaptic efficacies are considered essential for learning and memory. However, it is not known how the underlying functional components of synaptic transmission change over long time scales. To address this question, we studied cortical sy ...

Soc Neuroscience2013

Microengineered analytical tools for cell-based studies in environmental monitoring, pharmacology and neuroscience

Sara Talaei

Monitoring cells’ Tehavior in-vitro and evaluation of their response to different types of stimulations are the major oTjectives in cell-Tased studies. The results of these studies answer questions on the physiology of the cells, cell-to-cell signaling and ...

EPFL2013

Direct and Retrograde Transduction of Nigral Neurons with AAV6, 8, and 9 and Intraneuronal Persistence of Viral Particles

Patrick Aebischer, Bernard Schneider

Recombinant adeno-associated viral (AAV) vectors of serotypes 6, 8, and 9 were characterized as tools for gene delivery to dopaminergic neurons in the substantia nigra for future gene therapeutic applications in Parkinson's disease. While vectors of all th ...

Mary Ann Liebert2013

Downscaling the Analysis of Complex Transmembrane Signaling Cascades to Closed Attoliter Volumes

Horst Vogel, Rudolf Hovius, Luigino Grasso, Romain Wyss, Ghérici Hassaïne, Joachim Piguet, Michael Werner

Cellular signaling is classically investigated by measuring optical or electrical properties of single or populations of living cells. Here we show that ligand binding to cell surface receptors and subsequent activation of signaling cascades can be monitor ...

Public Library of Science2013

Nigrostriatal overabundance of alpha-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity

Patrick Aebischer, Marco Cantoni, Graham Knott, Ralf Schneggenburger, Jean-Charles Bensadoun, Özgür Genç, Wojciech Janusz Bobela, Safa Mohanna

alpha-Synuclein (alpha-syn) is a presynaptic protein present at most nerve terminals, but its function remains largely unknown. The familial forms of Parkinson's disease associated with multiplications of the alpha-syn gene locus indicate that overabundanc ...

Springer-Verlag2012

Cell-derived plasma membrane vesicles as minimal cells for analyzing transmembrane signaling

Horst Vogel, Rudolf Hovius, Luigino Grasso, Romain Wyss, Ghérici Hassaïne, Joachim Piguet, Michael Werner

Cellular signalling is classically investigated by measuring optical or electrical properties of single or populations of living cells. Here we show how cell-derived vesicles can be used for anlaysing transmembrane signalling. The vesicles are derived from ...

2012

Oligodendroglia metabolically support axons and contribute to neurodegeneration

Yiming Li, Pierre Magistretti, Sylvain Eric Lengacher, Luc Pellerin, Lin Jin

Oligodendroglia support axon survival and function through mechanisms independent of myelination, and their dysfunction leads to axon degeneration in several diseases. The cause of this degeneration has not been determined, but lack of energy metabolites s ...

2012

Spinal muscular atrophy pathogenic mutations impair the axonogenic properties of axonal-survival of motor neuron

Veronica Setola

The axonal survival of motor neuron (a-SMN) protein is a truncated isoform of SMN1, the spinal muscular atrophy (SMA) disease gene. a-SMN is selectively localized in axons and endowed with remarkable axonogenic properties. At present, the role of a-SMN in ...

Wiley-Blackwell2012

A Semisynthetic Fluorescent Sensor Protein for Glutamate

Kai Johnsson, Luc Reymond, Rudolf Griss, Matthias Albert Brun, Kui Thong Tan

We report the semisynthesis of a fluorescent glutamate sensor protein on cell surfaces. Sensor excitation at 547 nm yields a glutamate-dependent emission spectrum between 550 and 700 nm that can be exploited for ratiometric sensing. On cells, the sensor di ...

2012

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