Horst VogelHorst Vogel est né en 1948 à Würzburg, Allemagne. Après ses études en chimie, il obtient le diplôme de chimie en 1974 de l'Université de Würzburg.Il entreprend ensuite un travail de doctorat au Max-Planck Institut für Biophysikalische Chemie de Göttingen, et obtient en 1978 le grade de docteur ès sciences de l'Université de Göttingen. De 1978 à 1983 il effectue des recherches au Max-Planck Institut für Biologie à Tübingen et en 1984, il rejoint le Biocentre à Bâle où il travaille jusqu'en 1989, effectuant une année au Karolinska Institute à Stockholm. En 1989, Horst Vogel rejoint l'institut de chimie physique de l'EPFL où il dirige un groupe travaillant dans les domaines de la biophysique et de la bioélectronique.
Depuis le 1er octobre 1994 il est profeseur en chimie physique des polymères et membranes au Département de chimie de EPFL. Ses intérêts de recherche sont l'étude de la structure et de la dynamique de récepteurs membranaires et l'auto-assemblage des biomolécules aux interfaces pour développer de nouveaux biocapteurs dans le domaine de micro- et nanotechnologie. Il enseigne les sciences du vivant, la biophysique et biochimie, et des chapitres concernant la biotechnologie.
Dipl. in Chemistry1974-Univ. Würzburg, DE
Ph.D.-1978-MPI für Biophys. Chemie, Göttingen, DE
Daniel ConstamDaniel Constam received his doctoral degree in Natural Sciences from ETH Zürich in the neuroimmunology group of Adriano Fontana (1993). For postdoctoral studies, he joined the laboratory of Elizabeth Robertson as an EMBO fellow at Harvard University to characterize proprotein convertase (PC) functions in mouse models of early embryogenesis (1994-1999). As an ISREC group leader (>2000) and Associate Professor at EPFL (>2007), he initially continued to study pluripotency and lineage differentiation during development and found that several secreted PCs jointly regulate cell-cell adhesion and TGFβ signaling pathways at the cross-roads of stem cell and cancer biology. To map the proteolytic activity of PCs and their relative distribution in exocytic or endocytic vesicles, his lab developed PC-specific FRET sensors for high resolution live imaging in normal cells and in tumour-host interactions. His studies on TGFβ signaling also identified the RNA-binding protein Bicc1 and its self-polymerization in membrane-less organelles as regulators of mRNA translation and cell metabolism that cooperate with primary cilia to prevent cystic growth in renal tubules and in pancreatic and bile ducts.
Florian Maria WurmFlorian Wurm received his academic training as a Biologist and Molecular Geneticist at the University of Giessen. He joined the Hoechst AG (Behringwerke) in Marburg as head of a laboratory in Virology. Working with immortalized mammalian cells for the establishment of production processes for alpha-interferons provided the first opportunity to combine basic research with medical application. In 1984 he joined Harvard Medical School in Boston as a Research Fellow in Molecular Biology. 1986 he took an offer from Genentech Inc. in San Francisco to work in Process Sciences on the development of large scale manufacturing processes for recombinant proteins. There he has held a number of leading positions and has acquired intimate knowledge in the generation of protein pharmaceuticals in mammalian cells in bioreactors (a number of which are now marketed products). In 1995 he joined the EPFL as a Professor for Biotechnology. Wurm has published more than 250 scientific papers and holds more than 20 patents/patent-applications. His H-index stands at 60 in 2021. He was Chairman (2005-2009) and is member of the Executive Board of the European Society of Animal Cell Technology (ESACT). He serves as a consultant to the pharmaceutical Biotech Industry, mainly in the fields of animal cell technology for recombinant protein production and in regulatory affairs. He works as a scientific reviewer and editior/asscciate editor for a number of international journals in the Biotech field. F.M. Wurm teaches classes to pre- and postgraduate students in the fields of Molecular and Cellular Biotechnology.
He was founder and Chief Scientific Officer of ExcellGene SA, a 2001 established company in Monthey, Switzerland. He took the position of President and CEO of ExcellGene in 2015. He retired from the CEO position in 2017 and continues to be President and Chief Scientific Officer of ExcellGene.
In 2008 Dr. Wurm was appointed Visiting Professor for Biotechnology at Jinan University in Guangzhou, China. He retired from his position at the EPFL in 2015. His laboratory is closed. With his team at ExcellGene and in collaboration with Dr. Paco Pino, Director of R&D, he continues to explore manufacturing sciences with animal cells in bioreactors.
Jean-Yves Le BoudecJean-Yves Le Boudec is full professor at EPFL and fellow of the IEEE. He graduated from Ecole Normale Superieure de Saint-Cloud, Paris, where he obtained the Agregation in Mathematics in 1980 (rank 4) and received his doctorate in 1984 from the University of Rennes, France. From 1984 to 1987 he was with INSA/IRISA, Rennes. In 1987 he joined Bell Northern Research, Ottawa, Canada, as a member of scientific staff in the Network and Product Traffic Design Department. In 1988, he joined the IBM Zurich Research Laboratory where he was manager of the Customer Premises Network Department. In 1994 he joined EPFL as associate professor. His interests are in the performance and architecture of communication systems. In 1984, he developed analytical models of multiprocessor, multiple bus computers. In 1990 he invented the concept called "MAC emulation" which later became the ATM forum LAN emulation project, and developed the first ATM control point based on OSPF. He also launched public domain software for the interworking of ATM and TCP/IP under Linux. He proposed in 1998 the first solution to the failure propagation that arises from common infrastructures in the Internet. He contributed to network calculus, a recent set of developments that forms a foundation to many traffic control concepts in the internet. He earned the Infocom 2005 Best Paper award, with Milan Vojnovic, for elucidating the perfect simulation and stationarity of mobility models, the 2008 IEEE Communications Society William R. Bennett Prize in the Field of Communications Networking, with Bozidar Radunovic, for the analysis of max-min fairness and the 2009 ACM Sigmetrics Best Paper Award, with Augustin Chaintreau and Nikodin Ristanovic, for the mean field analysis of the age of information in gossiping protocols. He is or has been on the program committee or editorial board of many conferences and journals, including Sigcomm, Sigmetrics, Infocom, Performance Evaluation and ACM/IEEE Transactions on Networking. He co-authored the book "Network Calculus" (2001) with Patrick Thiran and is the author of the book "Performance Evaluation of Computer and Communication Systems" (2010).
