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In the United States approximately 50 million people suffer from low back pain. In the 20-50 years age group, this is the most important and expensive health care problem. The causes of low back pain are various. A herniated disk or spinal stenosis may tra ...
Many neurophysiological and behavioural studies suggested that the lower limb endpoint might be a centrally represented variable within the gravity reference frame and effectively controlled during the locomotion. This investigation examines the effects of ...
The spike timing in rhythmically active interneurons in the mammalian spinal locomotor network varies from cycle to cycle. We tested the contribution from passive membrane properties to this variable firing pattern, by measuring the reliability of spike ti ...
Spinal cord stimulation (i.e. the electrical stimulation of the dorsal columns of the spinal cord) isincreasingly used for the treatment of intractable pain syndromes due to vascular or neurogenicdisorders. Despite well-established safety and efficacy in p ...
The present work was performed to determine the ability of neurotrophic factors to allow axonal regeneration across a 15-mm-long gap in the rat sciatic nerve. Synthetic nerve guidance channels slowly releasing NGF and GDNF were fabricated and sutured to th ...
Locomotion in vertebrates is controlled by central pattern generators in the spinal cord. The roles of specific network architecture and neuronal properties in rhythm generation by such spinal networks are not fully understood. We have used multisite recor ...
Regeneration of the human facial nerve after lesion is often limited, leading to severe functional impairments, in particular when repair is delayed for several months, when cross-facial nerve grafts have to be performed, or in elderly patients. To improve ...
BACKGROUND: Notch signaling regulates multiple differentiation processes and cell fate decisions during both invertebrate and vertebrate development. Numb encodes an intracellular protein that was shown in Drosophila to antagonize Notch signaling at binary ...
We have selectively inhibited Notch1 signaling in oligodendrocyte precursors (OPCs) using the Cre/loxP system in transgenic mice to investigate the role of Notch1 in oligodendrocyte (OL) development and differentiation. Early development of OPCs appeared n ...
Rat spinal networks generate a spontaneous rhythmic output directed to motoneurons under conditions of increased excitation or of disinhibition. It is not known whether these differently induced rhythms are produced by a common rhythm generator. To investi ...
