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The proposition that declarative memory deficits are systematically related to smaller hippocampal Volume was tested in a relatively large sample (n = 95) of U.S. military veterans with and without combat-related posttraumatic stress disorder. This correla ...
Chromatin remodeling through histone posttranslational modifications (PTMs) and DNA methylation has recently been implicated in cognitive functions, but the mechanisms involved in such epigenetic regulation remain poorly understood. Here, we show that prot ...
Presenting stimuli of two or more stimulus types randomly interleaved, so called roving, disrupts perceptual learning in many paradigms. Recently, it was shown that no disruption occurs when Gabor stimuli were presented interleaved in sequence, instead of ...
To make sense out of a continuously changing visual world, people need to integrate features across space and time. Despite more than a century of research, the mechanisms of features integration are still a matter of debate. To examine how temporal and sp ...
Humans and animals learn by modifying the synaptic strength between neurons, a phenomenon known as synaptic plasticity. These changes can be induced by rather short stimuli (lasting, for instance, only a few seconds), yet, in order to be useful for long-te ...
Intensive research over the past few years has provided evidence, that stress is a potent modulator of brain function and cognition. In particular cognitive and emotional processes have been shown to be susceptible to modulation by stress. Whereas acute st ...
Agomelatine, a novel antidepressant with established clinical efficacy, acts as a melatonin receptor agonist and 5-HT(2C) receptor antagonist. As stress is a significant risk factor in the development of depression, we sought to determine if chronic agomel ...
Stress is known to be a potent modulator of brain function and cognition. While prolonged and/or excessive stress generally exerts negative effects on learning and memory processes, acute stress can have differential effects on memory function depending on ...
The human mind is continuously involved in "projecting" the self in time in order to process past memories and predict future occurrences. "Self-projection" in time involves episodic and spatial memory, relying on medial-temporal structures, but also engag ...
Recent neurophysiological studies have associated focal-task specific dystonia (FTSD) with impaired inhibitory function. However, it remains unknown whether FTSD also affects the inhibition (INH) of long-term overlearned motor programs. Consequently, we in ...