Concept

Membrane hémi-perméable

Publications associées (787)

Molecular basis for the regulation of the nuclear receptor LRH-1

Kristina Schoonjans, Matthias Alexander Sokrates Stein

Liver receptor homolog-1 (LRH-1) is a nuclear receptor (NR) with diverse functions in development, differentiation and metabolism and has been extensively studied in the enterohepatic system. While initially described as an orphan NR, recent studies sugges ...

Current Biology Ltd2015

Effect of 1-butyl-3-methylimidazolium iodide containing electrospun poly(vinylidene fluoride-co-hexafluoropropylene) membrane electrolyte on the photovoltaic performance of dye-sensitized solar cells

Paul Joseph Dyson, Zhaofu Fei

Electrospun poly(vinylidene fluoride-co-hexafluoropropylene) (PVdF-HFP) membrane was prepared from a solution of 16 wt % of PVdF-HFP containing acetone/N,N-dimethyl acetamide (7:3 wt %). The prepared electrospun PVdF-HFP membrane (esPM) was then soaked in ...

Wiley-Blackwell2015

Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death

Hilal Lashuel, Anne-Laure Mahul Mellier, Nadine Aït Bouziad, Bohumil Maco, Filip Vercruysse

The role of extracellular α-synuclein (α-syn) in the initiation and the spreading of neurodegeneration in Parkinson's disease (PD) has been studied extensively over the past 10 years. However, the nature of the α-syn toxic species and the molecular mechani ...

Nature Publishing Group2015

Bioengineering approaches to emulate the stem cell niche

Sylke Höhnel

Stem cell therapies hold tremendous potential for tissue and organ regeneration. Yet, there remains significant need for better ex vivo culture and manipulation methods. On the one hand, many tissue-specific stem cells cannot be propagated without causing ...

EPFL2015

Identification of Soft Matter Binding Peptide Ligands Using Phage Display

Harm-Anton Klok

Phage display is a powerful tool for the selection of highly affine, short peptide ligands. While originally primarily used for the identification of ligands to proteins, the scope of this technique has significantly expanded over the past two decades. Pha ...

Amer Chemical Soc2015

Iron regulatory proteins and their role in controlling iron metabolism

Cellular iron homeostasis is regulated by post-transcriptional feedback mechanisms, which control the expression of proteins involved in iron uptake, release and storage. Two cytoplasmic proteins with mRNA-binding properties, iron regulatory proteins 1 and ...

Royal Soc Chemistry2015

Assessment of Pseudo-Bilayer Structures in the Heterogate Germanium Electron-Hole Bilayer Tunnel Field-Effect Transistor

Mihai Adrian Ionescu, Cem Alper, José Luis Padilla de la Torre

We investigate the effect of pseudo-bilayer configurations at low operating voltages (

American Institute of Physics2015

NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane

Pierre Gönczy, Coralie Busso, Sachin Kotak

The positioning and the elongation of the mitotic spindle must be carefully regulated. In human cells, the evolutionary conserved proteins LGN/Gai1-3 anchor the coiled-coil protein NuMA and dynein to the cell cortex during metaphase, thus ensuring proper s ...

2014

A fluorogenic probe for SNAP-tagged plasma membrane proteins based on the solvatochromic molecule Nile Red

Kai Johnsson, Rudolf Hovius, Luc Reymond, Howard Riezman, Efthymia Prifti

A fluorogenic probe for plasma membrane proteins based on the dye Nile Red and SNAP-tag is introduced. It takes advantage of Nile Red, a solvatochromic molecule highly fluorescent in an apolar environment, such as cellular membranes, but almost dark in a p ...

Amer Chemical Soc2014

Perturbations of the Straight Transmembrane alpha-Helical Structure of the Amyloid Precursor Protein Affect Its Processing by gamma-Secretase

Matteo Dal Peraro, Patrick Fraering, Mitko Dimitrov, Thomas Lemmin

Background: Amyloid- neurotoxicity depends on the specificity of the proteolytic cleavage of the amyloid precursor protein (APP) transmembrane domain. Results: The APP transmembrane -helix is straight in a biological membrane bilayer. Conclusion: The flexi ...

American Society for Biochemistry and Molecular Biology2014

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