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Metal complexation by dissolved organic matter, as humic acids, is considered to decrease metal bioavailability by lowering the free metal ion concentration. However, dissolved organic matter adsorption on cell surfaces can modify cell membrane properties, ...
Recently discovered bacterial homologues of eukaryotic pentameric ligand-gated ion channels, such as the Gloeobacter violaceus receptor (GLIC), are increasingly used as structural and functional models of signal transduction in the nervous system. Here we ...
An analytical calculation of the acoustic transmission loss of sound propagating through a thin cylindrically curved piezoelectric membrane, which is rigidly clamped at its straight ends, is presented. The membrane is placed inside an acoustic tube and con ...
Increasing evidence suggests that phosphorylation may play an important role in the oligomerization, fibrillogenesis, Lewy body (LB) formation, and neurotoxicity of alpha-synuclein (alpha-syn) in Parkinson disease. Herein we demonstrate that alpha-syn is p ...
The applicability of extremely thin non-electroneutral membranes for ion-selective electrodes (ISEs) is investigated. A theoretical treatment of potential and concentration profiles in space-charge membranes of
In this thesis, the wafer-scale fabrication of SiN membranes, Au films and Au membranes with arrays of sub-µm holes is described. Two conceptually different processes (1) and (2) were developed, both of which are based on nanosphere lithography (NSL) with ...
Virus filtration by size exclusion is a robust means of eliminating viruses in blood or pharma products. Porous polymer membranes with a narrow size distribution are used to allow passage of the protein product but retain viruses. The chosen polymer must r ...
We describe an optical method capable of tracking a single fluorescent molecule with a flexible choice of high spatial accuracy (~10–20 nm standard deviation or ~20–40 nm full-width-at-half-maximum) and temporal resolution (< 1 ms). The fluorescence signal ...
Biological cells continuously change shape allowing essential functions such as cell motility, vesicle-mediated release/uptake of soluble and membrane components or nanotube-mediated cell–cell communications. Here we use single cell micromanipulation to in ...
An emerging concept in cell signaling is the natural role of reactive oxygen species such as hydrogen peroxide (H2O2) as beneficial messengers in redox signaling pathways. The nature of H2O2 signaling is confounded, however, by difficulties in tracking it ...