Publications associées à Interaction protéine-protéine

Allosteric modulators enhance agonist efficacy by increasing the residence time of a GPCR in the active state

Here, the authors use smFRET to assess the structural dynamics of metabotropic glutamate receptor mGlu2 and show that a positive allosteric modulator or the Gi protein stabilize mGlu2 in the glutamate-induced active state, leading to the full activation of ...

NATURE PORTFOLIO2021

Optogenetic control of Neisseria meningitidis Cas9 genome editing using an engineered, light-switchable anti-CRISPR protein

Bruno Emanuel Ferreira De Sousa Correia, Zander Harteveld, Julius Valten Upmeier Zu Belzen

Optogenetic control of CRISPR-Cas9 systems has significantly improved our ability to perform genome perturbations in living cells with high precision in time and space. As new Cas orthologues with advantageous properties are rapidly being discovered and en ...

2021

3D Structure From 2D Microscopy Images Using Deep Learning

Suliana Manley, Christian Sieben

Understanding the structure of a protein complex is crucial in determining its function. However, retrieving accurate 3D structures from microscopy images is highly challenging, particularly as many imaging modalities are two-dimensional. Recent advances i ...

Lausanne2021

HP agents and biochemical interactions

Hikari Ananda Infinity Yoshihara

The intense but transient increase in nuclear magnetic resonance signal provided by dynamic nuclear polarization (DNP) has enabled a range of new applications, including rapid, minimally-invasive metabolic imaging at the second timescale. This chapter prov ...

Academic Press2021

In Vitro-Evolved Peptides Bind Monomeric Actin and Mimic Actin-Binding Protein Thymosin-β4

Christian Heinis, Jonas Alfred Karl Wilbs, Davide Bertoldo, Ganesh Kumar Mothukuri, Raphael Johannes Gübeli

Actin is the most abundant protein in eukaryotic cells and is key to many cellular functions. The filamentous form of actin (F-actin) can be studied with help of natural products that specifically recognize it, as for example fluorophore-labeled probes of ...

2021

Bottom-up de novo design of functional proteins with complex structural features

Luciano Andres Abriata, Bruno Emanuel Ferreira De Sousa Correia, Sandrine Madeleine Suzanne Georgeon, Leo Scheller, Jaume Bonet Martinez, Fabian Sesterhenn, Stéphane Rosset, Che Yang, Eva Anna van Aalen

De novo protein design has enabled the creation of new protein structures. However, the design of functional proteins has proved challenging, in part due to the difficulty of transplanting structurally complex functional sites to available protein structur ...

NATURE RESEARCH2021

Recommendation on Live-Streaming Platforms: Dynamic Availability and Repeat Consumption

Karl Aberer, Jérémie Rappaz

Live-streaming platforms broadcast user-generated video in real-time. Recommendation on these platforms shares similarities with traditional settings, such as a large volume of heterogeneous content and highly skewed interaction distributions. However, sev ...

ASSOC COMPUTING MACHINERY2021

The human telomeric proteome during telomere replication

Joachim Lingner, Thomas Frédéric Lunardi, Aleksandra Vancevska, Gérald Joseph Paul Lossaint, Chih-Yi Gabriela Lin

Telomere shortening can cause detrimental diseases and contribute to aging. It occurs due to the end replication problem in cells lacking telomerase. Furthermore, recent studies revealed that telomere shortening can be attributed to difficulties of the sem ...

OXFORD UNIV PRESS2021

The functional proteome landscape of Escherichia coli

Camille Véronique Bernadette Goemans

Recent developments in high-throughput reverse genetics1,2 have revolutionized our ability to map gene function and interactions3,4,5,6. The power of these approaches depends on their ability to identify functionally associated genes, which elicit similar ...

2020

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Interaction protéine-protéine

Allosteric modulators enhance agonist efficacy by increasing the residence time of a GPCR in the active state

Optogenetic control of Neisseria meningitidis Cas9 genome editing using an engineered, light-switchable anti-CRISPR protein

3D Structure From 2D Microscopy Images Using Deep Learning

HP agents and biochemical interactions

In Vitro-Evolved Peptides Bind Monomeric Actin and Mimic Actin-Binding Protein Thymosin-β4

Bottom-up de novo design of functional proteins with complex structural features

Cell penetration efficiency analysis of different atomic force microscopy nanoneedles into living cells

Recommendation on Live-Streaming Platforms: Dynamic Availability and Repeat Consumption

The human telomeric proteome during telomere replication

The functional proteome landscape of Escherichia coli

Graph Chatbot

Chattez avec Graph Search

HP agents and biochemical interactions

Optogenetic control of Neisseria meningitidis Cas9 genome editing using an engineered, light-switchable anti-CRISPR protein

Allosteric modulators enhance agonist efficacy by increasing the residence time of a GPCR in the active state

3D Structure From 2D Microscopy Images Using Deep Learning

Bottom-up de novo design of functional proteins with complex structural features

In Vitro-Evolved Peptides Bind Monomeric Actin and Mimic Actin-Binding Protein Thymosin-β4

Cell penetration efficiency analysis of different atomic force microscopy nanoneedles into living cells

The functional proteome landscape of Escherichia coli

Recommendation on Live-Streaming Platforms: Dynamic Availability and Repeat Consumption

The human telomeric proteome during telomere replication