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Publications associées (18)

High-content, arrayed compound screens with rhinovirus, influenza A virus and herpes simplex virus infections

Viruses are genetically and structurally diverse, and outnumber cells by orders of magnitude. They can cause acute and chronic infections, suppress, or exacerbate immunity, or dysregulate survival and growth of cells. To identify chemical agents with pro- ...

2022

Solid-phase peptide synthesis on disulfide-linker resin followed by reductive release affords pure thiol-functionalized peptides

Christian Heinis, Peter Matei Frisius Pânzar, Alexander Lund Nielsen, Manuel Leonardo Merz, Ganesh Kumar Mothukuri, Zsolt Bognár

Thiol groups are suitable handles for site-selectively modifying, immobilizing or cyclizing individual peptides or entire peptide libraries. A limiting step in producing the thiol-functionalized peptides is the chromatographic purification, which is partic ...

ROYAL SOC CHEMISTRY2022

A releasable disulfide-linked peptide tag facilitates the synthesis and purification of short peptides

Christian Heinis, Yu Teng Wu, Alessandro Zorzi, Jack Peter Christopher Williams

Combinatorial cyclization of hundreds to thousands of random linear peptides by structurally diverse chemical linkers offers access to large macrocyclic compound libraries. A bottleneck in the development of such libraries is the preparation of large numbe ...

2020

Towards an Adaptive Upper Limb Rehabilitation Game with Tangible Robots

Pierre Dillenbourg, Friedhelm Christoph Hummel, Pablo Maceira Elvira, Wafa Monia Benkaouar Johal, Maximilian Jonas Wessel, Ayberk Özgür, Louis Pierre Faucon, Arzu Güneysu Özgür, Andéol Geoffroy Cadic-Melchior

A key feature of a successful game is its ability to provide the player with an adequate level of challenge. However, the objective of difficulty adaptation in serious games is not only to maintain the player’s motivation by challenging, but also to ensure ...

2019

Towards an Adaptive Upper Limb Rehabilitation Game with Tangible Robots

Pierre Dillenbourg, Friedhelm Christoph Hummel, Pablo Maceira Elvira, Wafa Monia Benkaouar Johal, Maximilian Jonas Wessel, Ayberk Özgür, Louis Pierre Faucon, Andéol Geoffroy Cadic-Melchior

A key feature of a successful game is its ability to provide the player with an adequate level of challenge. However, the objective of difficulty adaptation in serious games is not only to maintain the player's motivation by challenging, but also to ensure ...

IEEE2019

Electronic metal–organic framework sensors

Kyriakos Stylianou, Arunraj Chidambaram

Metal–organic frameworks (MOFs), a class of crystalline and porous materials, are synthesized through the self-assembly of organic ligands and inorganic metal nodes (ions or clusters). For the past few years, MOFs have been in the limelight due to their st ...

2018

Intrafascicular electrode implant

Silvestro Micera, Stanisa Raspopovic, Francesco Maria Petrini

An implantable device for intrafascicular stimulation and/or sensing of a peripheral nerve, including a blocking element adapted for wrapping a nerve, comprising an access point and an exit point, and an electrode adapted to traverse the blocking element v ...

2018

A Nerve-on-a-Chip Platform to Facilitate the Design of Peripheral Nerve Interfaces

Stéphanie Lacour, Diego Ghezzi, Sandra Gribi

Peripheral nerves are often interfaced with cuff-based and microchannel-based nerve implants so that neural activity may be stimulated, inhibited and/or recorded. In vivo evaluation of these interfaces is mandatory but often time-consuming, and focused on ...

2017

Towards an (∞,2)-category of homotopy coherent monads in an ∞-cosmos

Dimitri Zaganidis

This thesis is part of a program initiated by Riehl and Verity to study the category theory of (infinity,1)-categories in a model-independent way. They showed that most models of (infinity,1)-categories form an infinity-cosmos K, which is essentially a cat ...

EPFL2017

Epigenetic approach for angiostatic therapy: promising combinations for cancer treatment

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Ume-Gulsoom Abdul, Marije Trudi Te Winkel

Cancer cells are often dependent on epigenetic pathways for their survival. Consequently, drugs that target the epigenome, rather than the underlying DNA sequence, are currently attracting considerable attention. In recent years, the first epigenetic drugs ...

Springer Verlag2017

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