Publications associées à Virtual karyotype

Chromosomal contacts connect loci associated with autism, BMI and head circumference phenotypes

Bart Deplancke, Marion Leleu, Nele Gheldof, Loyse Hippolyte

Copy number variants (CNVs) are major contributors to genomic imbalance disorders. Phenotyping of 137 unrelated deletion and reciprocal duplication carriers of the distal 16p11.2 220 kb BP2-BP3 interval showed that these rearrangements are associated with ...

Springer Nature2017

Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma

Elisa Oricchio, Natalya Katanayeva, Elena Battistello, Stephanie Jocelyne Sungalee, Maria Christine Donaldson, Giovanni Ciriello

Follicular lymphoma (FL) is an incurable form of B cell lymphoma. Genomic studies have cataloged common genetic lesions in FL such as translocation t(14;18), frequent losses of chromosome 6q, and mutations in epigenetic regulators such as EZH2 Using a focu ...

American Association for the Advancement of Science2017

User-Friendly Image-Based Segmentation and Analysis of Chromosomes

Michaël Unser, Florian Maria Wurm, Lucia Baldi Unser, Ricard Delgado Gonzalo, Virginie Sophie Uhlmann

We designed two efficient and user-friendly tools for the segmentation and analysis of images containing chromosomes or, more generally, rod-shaped elements that are spread on microscopic slides. The segmentation tool allows to automatically extract the pr ...

IEEE2016

Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis

Oliver Hantschel, Sina Maren Reckel

The amount of genomic information about leukemia cells currently far exceeds our overall understanding of the precise genetic events that ultimately drive disease development and progression. Effective implementation of personalized medicine will require t ...

American Association for Cancer Research2016

The 16p11.2 locus modulates brain structures common to autism, schizophrenia and obesity

Nouchine Hadjikhani, Loyse Hippolyte

Anatomical structures and mechanisms linking genes to neuropsychiatric disorders are not deciphered. Reciprocal copy number variants at the 16p11.2 BP4-BP5 locus offer a unique opportunity to study the intermediate phenotypes in carriers at high risk for a ...

Nature Publishing Group2015

On Non-cooperative Genomic Privacy

Jean-Pierre Hubaux, Mathias Jacques Jean-Marc Humbert, Amalio Telenti, Erman Ayday

Over the last few years, the vast progress in genome sequencing has highly increased the availability of genomic data. Today, individuals can obtain their digital genomic sequences at reasonable prices from many online service providers. Individuals can st ...

2015

Interdependent Privacy Games: The Case of Genomics

Jean-Pierre Hubaux, Mathias Jacques Jean-Marc Humbert, Amalio Telenti, Erman Ayday

2015

Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines

Bart Deplancke, Andreas Massouras, Sandy Lee, Yi Han, Yiming Zhu

The Drosophila melanogaster Genetic Reference Panel (DGRP) is a community resource of 205 sequenced inbred lines, derived to improve our understanding of the effects of naturally occurring genetic variation on molecular and organismal phenotypes. We used a ...

Cold Spring Harbor Laboratory Press2014

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Virtual karyotype

Genomic Instability Profiles at the Single Cell Level in Mouse Colorectal Cancers of Defined Genotypes

Improvement of breast cancer diagnosis through microfluidics

Chromosomal contacts connect loci associated with autism, BMI and head circumference phenotypes

Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma

User-Friendly Image-Based Segmentation and Analysis of Chromosomes

Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis

The 16p11.2 locus modulates brain structures common to autism, schizophrenia and obesity

On Non-cooperative Genomic Privacy

Interdependent Privacy Games: The Case of Genomics

Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines

Graph Chatbot

Chattez avec Graph Search

Improvement of breast cancer diagnosis through microfluidics

Genomic Instability Profiles at the Single Cell Level in Mouse Colorectal Cancers of Defined Genotypes

Chromosomal contacts connect loci associated with autism, BMI and head circumference phenotypes

Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma

User-Friendly Image-Based Segmentation and Analysis of Chromosomes

Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis

The 16p11.2 locus modulates brain structures common to autism, schizophrenia and obesity

On Non-cooperative Genomic Privacy

Interdependent Privacy Games: The Case of Genomics

Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines