Publications associées à Pore nucléaire

The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

Hilal Lashuel, Graham Knott, Marion Leleu, Fabien Kuttler, Anne-Laure Mahul Mellier, Johannes Burtscher, Niran Maharjan, Laura Emmeline H Weerens

Parkinson’s disease (PD) is characterized by the accumulation of misfolded and aggregated α-synuclein (α-syn) into intraneuronal inclusions named Lewy bodies (LBs). Although it is widely believed that α-syn plays a central role in the pathogenesis of PD, t ...

2020

Alternative interaction sites in the influenza A virus nucleoprotein mediate viral escape from the importin-alpha 7 mediated nuclear import pathway

Jaume Bonet Martinez, Sebastian Beck

Influenza A viruses are able to adapt to restrictive conditions due to their high mutation rates. Importin-alpha 7 is a component of the nuclear import machinery required for avian-mammalian adaptation and replicative fitness in human cells. Here, we eluci ...

WILEY2019

Single-molecule kinetics of pore assembly by the membrane attack complex

Georg Fantner, Adrian Pascal Nievergelt

The membrane attack complex (MAC) is a hetero-oligomeric protein assembly that kills pathogens by perforating their cell envelopes. The MAC is formed by sequential assembly of soluble complement proteins C5b, C6, C7, C8 and C9, but little is known about th ...

Springer2019

Light-Enhanced Blue Energy Generation Using MoS2 Nanopores

Aleksandra Radenovic, Andras Kis, Martina Lihter, Michael Graf, Dmitrii Unuchek, Aditya Sarathy

Blue energy relies on the chemical potential difference between solutions of high and low ionic concentrations, potentially providing an independent energy source at estuaries around the world. The energy conversion relies on reverse electrodialysis via io ...

CELL PRESS2019

Quantitative relationships between SMAD dynamics and target gene activation kinetics in single live cells

Felix Naef, David Michael Suter, Torgil Elias Friman, Onur Tidin

The transduction of extracellular signals through signaling pathways that culminate in a transcriptional response is central to many biological processes. However, quantitative relationships between activities of signaling pathway components and transcript ...

2019

Mechanosensitive Fluorescent Probes to Image Membrane Tension in Mitochondria, Endoplasmic Reticulum, and Lysosomes

Suliana Manley, Stefan Matile, Dora Mahecic

Measuring forces inside cells is particularly challenging. With the development of quantitative microscopy, fluorophores which allow the measurement of forces became highly desirable. We have previously introduced a mechanosensitive flipper probe, which re ...

AMER CHEMICAL SOC2019

Post-transcriptional regulation of Nrf2-mRNA by the mRNA-binding proteins HuR and AUF1

Yimon Aye, Jesse Poganik, Xuyu Liu

The nuclear factor erythroid 2 related factor 2 (Nrf2) signaling axis is a target of covalent drugs and bioactive native electrophiles. However, much of our understanding of Nrf2 regulation has been focused at the protein level. Here we report a post-trans ...

FEDERATION AMER SOC EXP BIOL2019

Cryo-EM structures of the pore-forming A subunit from the Yersinia entomophaga ABC toxin

Henning Paul-Julius Stahlberg

ABC toxins are pore-forming virulence factors produced by pathogenic bacteria. YenTcA is the pore-forming and membrane binding A subunit of the ABC toxin YenTc, produced by the insect pathogen Yersinia entomophaga. Here we present cryo-EM structures of Yen ...

Springer Science and Business Media LLC2019

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Pore nucléaire

The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

Alternative interaction sites in the influenza A virus nucleoprotein mediate viral escape from the importin-alpha 7 mediated nuclear import pathway

Single-molecule kinetics of pore assembly by the membrane attack complex

Light-Enhanced Blue Energy Generation Using MoS2 Nanopores

Quantitative relationships between SMAD dynamics and target gene activation kinetics in single live cells

Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality

Mechanosensitive Fluorescent Probes to Image Membrane Tension in Mitochondria, Endoplasmic Reticulum, and Lysosomes

Mitotic chromosome binding predicts transcription factor properties in interphase

Post-transcriptional regulation of Nrf2-mRNA by the mRNA-binding proteins HuR and AUF1

Cryo-EM structures of the pore-forming A subunit from the Yersinia entomophaga ABC toxin

Graph Chatbot

Chattez avec Graph Search

Alternative interaction sites in the influenza A virus nucleoprotein mediate viral escape from the importin-alpha 7 mediated nuclear import pathway

Light-Enhanced Blue Energy Generation Using MoS2 Nanopores

Quantitative relationships between SMAD dynamics and target gene activation kinetics in single live cells

Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality

Mitotic chromosome binding predicts transcription factor properties in interphase

Cryo-EM structures of the pore-forming A subunit from the Yersinia entomophaga ABC toxin

Post-transcriptional regulation of Nrf2-mRNA by the mRNA-binding proteins HuR and AUF1

Mechanosensitive Fluorescent Probes to Image Membrane Tension in Mitochondria, Endoplasmic Reticulum, and Lysosomes

The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

Single-molecule kinetics of pore assembly by the membrane attack complex