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This thesis focuses on intracranial aneurysms and particularly on the effect of blood flow in the three major phases that characterize an aneurysm: initiation, growth and rupture. As it stands today, blood flow is the major driver of this disease. The unde ...
Aging affects elastin, a key component of the arterial wall integrity and functionality. Elastin degradation in cerebral vessels is associated with cerebrovascular disease. The goal of this study is to assess the biomechanical properties of human cerebral ...
This paper presents the results of the Virtual Intracranial Stenting Challenge (VISC) 2007, an international initiative whose aim was to establish the reproducibility of state-of-the-art haemodynamical simulation techniques in subject-specific stented mode ...
Cerebral vasospasm is a typical complication occurring after Subarachnoid Hemorrhage, which may
lead to delayed cerebral ischemia and death. The standard method to detect vasospasm is
angiography, which is an invasive procedure. Monitoring of vasospasm i ...
A micromechanically based model for the deformation, strength, and stress-rupture life of a ceramic-matrix composite is developed for materials that do not degrade by oxidative attack. The rupture model for a unidirectional composite incorporates fiber-str ...
PDZ domains are typical examples of binding motifs mediating the formation of protein-protein assemblies in many different cells. A quantitative characterization of the mechanisms intertwining structure, chemistry, and dynamics with the PDZ function repres ...
Despite extensive attention to abdominal aortic aneurysm (AAA) in the biomedical engineering community, its effect on aortic hemodynamics and arterial wave reflection has not been addressed before. We used experimental and numerical methods, relying on a r ...
A noninvasive test is needed to assess the severity of encephalopathy during fulminant hepatic failure. This feasibility study was designed to compare a noninvasive test, brain lactate measurement by magnetic resonance spectroscopy, with intracranial press ...
The intent of this thesis is to study the function of elastin in cerebral arteries, its contribution into the aging process and its implication into different cerebral diseases and in particular cerebral aneurysms. As of today, little is known on the genes ...