Concept

Syndrome hépato-rénal

Publications associées (13)

Étude intégrale d'un processus scan-to- BIM pour la mise à jour d'une maquette numérique

Le présent mémoire expose le travail réalisé pour la conception d’un processus de mise à jour de la géométrie d’une maquette numérique d’un bâtiment par l’intermédiaire de la méthode du scan-to- BIM. Réalisée au sein de l’entreprise HRS Real Estate SA (HRS ...

2023

Prognostic Implications of the Novel Pulmonary Hypertension Definition in Patients with Aortic Stenosis after Transcatheter Valve Replacement

Nikolaos Stergiopoulos, Georgios Rovas, Vasiliki Bikia, Stamatia Zoi Pagoulatou

Introduction: Pulmonary hypertension (PH), traditionally defined as a mean pulmonary artery pressure (PAP) >= 25 mmHg, is associated with poor outcomes in patients undergoing a transcatheter aortic valve replacement (TAVR) for severe aortic stenosis (AS). ...

MDPI2022

Probing perturbed hepatic metabolism in bile-duct-ligated rats with hyperpolarized 13C pyruvate and arginine

Rolf Gruetter, Cristina Ramona Cudalbu, Dmitri Firsov, Hikari Ananda Infinity Yoshihara

Detoxification of ammonia by the urea cycle and maintenance of glucose homeostasis by gluconeogenesis are two critical functions of the liver. The bile duct ligation (BDL) model of cirrhosis was used to test the ability of hyperpolarized [6-13C]arginine an ...

2018

Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides

Christian Heinis, Alessandro Zorzi, Jonas Alfred Karl Wilbs, Simon Jan Middendorp

The rapid renal clearance of peptides in vivo limits this attractive platform for the treatment of a broad range of diseases that require prolonged drug half-lives. An intriguing approach for extending peptide circulation times works through a 'piggy-back' ...

2017

Shear stress alterations in the celiac trunk of patients with a continuous-flow left ventricular assist device as shown by in-silico and in-vitro flow analyses

Alfio Quarteroni, Christian Vergara

BACKGROUND: The use of left ventricular assist devices (LVADs) to treat advanced cardiac heart failure is constantly increasing, although this device leads to high risk for gastrointestinal bleeding. METHODS: Using in-silico flow analysis, we quantified he ...

Elsevier Science Inc2017

Bicyclization and tethering to albumin yields long-acting Peptide antagonists

Christian Heinis, Alessandro Angelini, Shiyu Chen, Philippe Diderich, Julia Morales Sanfrutos

Proteolytically stable peptide architectures are required for the development of long-acting peptide therapeutics. In this work, we found that a phage-selected bicyclic peptide antagonist exhibits an unusually high stability in vivo and subsequently deciph ...

Amer Chemical Soc2012

A mathematical model of compartmentalized neurotransmitter metabolism in the human brain

Rolf Gruetter

After administration of enriched [1-13C]glucose, the rate of 13C label incorporation into glutamate C4, C3, and C2, glutamine C4, C3, and C2, and aspartate C2 and C3 was simultaneously measured in six normal subjects by 13C NMR at 4 Tesla in 45-ml volumes ...

2001

Hepatic blood flow in horses during the recuperative period from maximal exercise

Jeffrey Alan Hubbell

OBJECTIVE: To determine effects of walking or standing on hepatic blood flow of horses after brief, intense exercise. ANIMALS: 6 adult Thoroughbreds (4 mares, 2 geldings). PROCEDURE: Horses were preconditioned on a treadmill to establish uniform level of f ...

1998

Brain lactate by magnetic resonance spectroscopy during fulminant hepatic failure in the dog

Rolf Gruetter

A noninvasive test is needed to assess the severity of encephalopathy during fulminant hepatic failure. This feasibility study was designed to compare a noninvasive test, brain lactate measurement by magnetic resonance spectroscopy, with intracranial press ...

1998

1H NMR studies of glucose transport in the human brain

Rolf Gruetter

The difference between 1H nuclear magnetic resonance (NMR) spectra obtained from the human brain during euglycemia and during hyperglycemia is depicted as well-resolved glucose peaks. The time course of these brain glucose changes during a rapid increase i ...

1996

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