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The awake mammalian brain is functionally organized in terms of large-scale distributed networks that are constantly interacting. Loss of consciousness might disrupt this temporal organization leaving patients unresponsive. We hypothesize that characterizi ...
How the brain's white-matter anatomy constrains brain activity is an open question that might give insights into the mechanisms that underlie mental disorders such as schizophrenia. Chromosome 22q11.2 deletion syndrome (22q11DS) is a neurodevelopmental dis ...
Matching of a test signal to a reference word hypothesis forms the core of many speech processing problems, including objective speech intelligibility assessment. This paper first shows that the comparison of two speech signals can be formulated as matchin ...
Idiap2021
Research on microglia in Down syndrome (DS) has shown that microglial activation, increased inflammatory gene expression, and oxidative stress occur at different ages in DS brains. However, most studies resulted in simplistic definitions of microglia as qu ...
Basel2024
The objective of this study was to examine if patterns of resting-state brain activity and functional connectivity in cortical and subcortical regions in patients with early symptomatic amyotrophic lateral sclerosis (ALS) resemble those of behavioural vari ...
ELSEVIER SCI LTD2022
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Competitive state-of-the-art automatic pathological speech intelligibility measures typically rely on regression training on a large number of features, require a large amount of healthy speech training data, or are applicable only to phonetically balanced ...
Impaired speech intelligibility in motor speech disorders arising
due to neurological diseases negatively affects the communication
ability and quality of life of patients. Reliable and cost-effective
measures to automatically assess speec ...
2019
The authors used resting-state fMRI in a prospective study to compare whole-brain functional connectivity between patients with good and poor outcomes, implementing support vector machine learning. They automatically predicted coma outcome using resting-st ...
Speech intelligibility is an important assessment criterion of the communicative performance of pathological speakers. To assist clinicians in their assessment, time- and cost-efficient automatic intelligibility measures offering a repeatable and reliable ...
Neural evidence suggests that mechanisms associated with conscious access (i.e., the ability to report on a conscious state) are “all-or-none”. Upon crossing some threshold, neural signals are globally broadcast throughout the brain and allow conscious rep ...