Concept

Maladie de Parkinson

Publications associées (213)

Induction of A9 dopaminergic neurons from neural stem cells improves motor function in an animal model of Parkinsons disease

Neural stem cells (NSCs) are widely endorsed as a cell source for replacement strategies in neurodegenerative disease. However, their usefulness is currently limited by the inability to induce specific neurotransmitter phenotypes in these cells. In order t ...

Oxford University Press2008

An Active Contour-based Atlas Registration Model for Automatic Subthalamic Nucleus Targeting on MRI: Method and Validation

Jean-Philippe Thiran, Meritxell Bach Cuadra, Xavier Bresson, Valérie Duay, Francisco Javier Sanchez Castro

This paper presents a new non parametric atlas registration framework, derived from the optical flow model and the active contour theory, applied to automatic subthalamic nucleus (STN) targeting in deep brain stimulation (DBS) surgery. In a previous work, ...

Springer Berlin / Heidelberg2008

Viral vectors, animal models and new therapies for Parkinson's disease

Patrick Aebischer, Bernard Schneider, Romain Zufferey

The involvement of alpha-synuclein in familial forms of Parkinson's disease suggests a potential causative role in the pathogenesis. We have explored the possibility of generating animal models of Parkinson's disease by overexpressing alpha-synuclein in th ...

2008

Interferon alpha sequential regimen for treating cancers

The present invention relates to a method of treating cancers, especially those showing resistance to classical anti-pro liferative chemotherapy drugs. Further, the invention provides a specific interferon alpha sequential regimen for treating cancers, esp ...

2008

Differential neuroglycan C expression during retinal degeneration in Rpe65(-/-) mice

Pascal Escher

Purpose: An increased mRNA expression of the genes coding for the extracellular matrix proteins neuroglycan C (NGC), interphotoreceptor matrix proteoglycan 2 (IMPG2), and CD44 antigen (CD44) has been observed during retinal degeneration in mice with a targ ...

2008

Quantification of tremor and bradykinesia in Parkinson’s disease using a novel ambulatory monitoring system

Kamiar Aminian, Arash Salarian

An ambulatory system for quantification of tremor and bradykinesia in patients with Parkinson's disease (PD) is presented. To record movements of the upper extremities, a sensing units which included miniature gyroscopes, has been fixed to each of the fore ...

2007

Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation

Patrick Aebischer, Bernard Schneider

Missense mutations and extra copies of the alpha-Synuclein gene result in Parkinson disease (PD). Human stem and progenitor cells can be expanded from embryonic tissues and provide a source of non-transformed neural cells to explore the effects of these pa ...

Oxford University Press2007

Localization of electrodes in the subthalamic nucleus on magnetic resonance imaging

Jean-Philippe Thiran, Reto Meuli

Object. The authors describe a new method of localizing electrodes on magnetic resonance (MR) images and focus on the positions of both the most efficient contact and the electrode related to the MR imaging target. Methods. Thirty-one patients who had unde ...

2007

The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states

Hilal Lashuel

The third and most recently identified Parkinson's disease-linked variant of the neuronal protein alpha-synuclein to be identified (E46K) results in widespread brain pathology and early onset Parkinson symptoms (Zarranz et al. (2004) Ann. Neurol. 55, 164-1 ...

American Chemical Society2007

Transient striatal delivery of GDNF via encapsulated cells leads to sustained behavioral improvement in a bilateral model of Parkinson disease

Patrick Aebischer, Bernard Schneider, Jean-Charles Bensadoun, Christophe Lo Bianco

Numerous studies have shown the neuroprotective and regenerative benefits of glial cell line-derived neurotrophic factor (GDNF) in animal models of PD. Brain delivery of GDNF can, however, be associated with limiting side-effects in both primates and PD pa ...

2006

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