Publications associées à Lentivirus

A Baseline Cellular Antiviral State Is Maintained by cGAS and Its Most Frequent Naturally Occurring Variant rs610913

Jacques Fellay, Christian Axel Wandall Thorball, Shuting Xu

Upon recognition of aberrantly located DNA, the innate immune sensor cyclic GMP-AMP synthase (cGAS) activates stimulator of IFN genes (STING)/IFN regulatory factor (IRF)3-driven antiviral responses. In this study, we characterized the ability of a specific ...

AMER ASSOC IMMUNOLOGISTS2022

HIV-1 Vpr and p21 restrict LINE-1 mobility

Didier Trono, Priscilla Turelli, Flavia Marzetta

Long interspersed element-1 (LINE-1, L1) composes ∼17% of the human genome. However, genetic interactions between L1 and human immunodeficiency virus type 1 (HIV-1) remain poorly understood. In this study, we found that HIV-1 suppresses L1 retrotranspositi ...

2018

Recombinant protein production from stable mammalian cell lines and pools

David Hacker, Sowmya Balasubramanian

We highlight recent developments for the production of recombinant proteins from suspension-adapted mammalian cell lines. We discuss the generation of stable cell lines using transposons and lentivirus vectors (non-targeted transgene integration) and site- ...

Elsevier2016

Lentiviral Vector Mediated Transgenesis

Didier Trono, Isabelle Barde, Sonia Verp, Sandra Eloise Kjeldsen

The genetic manipulation of rodents through the generation of fully transgenic animals or via the modification of selective cells or organs is a procedure of paramount importance for biomedical research, either to address fundamental questions or to develo ...

2011

Homology-based identification of capsid determinants that protect HIV1 from human TRIM5α restriction

Didier Trono, Pierre Maillard, Olivier Michielin

The tropism of retroviruses relies on their ability to exploit cellular factors for their replication as well as to avoid host-encoded inhibitory activities such as TRIM5α. N-tropic murine leukemia virus is sensitive to human TRIM5α (huTRIM5α) restriction, ...

American Society for Biochemistry and Molecular Biology2010

Production and titration of lentiviral vectors

Didier Trono, Isabelle Barde

Lentiviral vectors have emerged over the last decade as powerful, reliable, and safe tools for stable gene transfer in a wide variety of mammalian cells. Unlike other vectors derived from oncoretroviruses, they allow for stable gene delivery into most nond ...

John Wiley & Sons2010

Generation of stable, high-producing cho cell lines by lentiviral vector-mediated gene transfer in serum-free suspension culture

Florian Maria Wurm, David Hacker, Agata Oberbek

Lentivirus-derived vectors (LVs) were studied for the generation of stable recombinant Chinese hamster ovary (CHO) cell lines. Stable pools and clones expressing the enhanced green fluorescent protein (eGFP) were selected via fluorescence-activated cell so ...

Wiley-Blackwell2010

Functional analysis and structural modeling of human APOBEC3G reveal the role of evolutionarily conserved elements in the inhibition of human immunodeficiency virus type 1 infection and Alu transposition

Didier Trono, Priscilla Turelli, Bastien Mangeat, Olivier Michielin

Retroelements are important evolutionary forces but can be deleterious if left uncontrolled. Members of the human APOBEC3 family of cytidine deaminases can inhibit a wide range of endogenous, as well as exogenous, retroelements. These enzymes are structura ...

2009

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Lentivirus

A Baseline Cellular Antiviral State Is Maintained by cGAS and Its Most Frequent Naturally Occurring Variant rs610913

HIV-1 Vpr and p21 restrict LINE-1 mobility

Recombinant protein production from stable mammalian cell lines and pools

Lentiviral Vector Mediated Transgenesis

Homology-based identification of capsid determinants that protect HIV1 from human TRIM5α restriction

Production and titration of lentiviral vectors

Generation of stable, high-producing cho cell lines by lentiviral vector-mediated gene transfer in serum-free suspension culture

Host determinants of HIV-1 control in African Americans

Functional analysis and structural modeling of human APOBEC3G reveal the role of evolutionarily conserved elements in the inhibition of human immunodeficiency virus type 1 infection and Alu transposition

Studies on lentiviral-mediated transgenesis

Graph Chatbot

Chattez avec Graph Search

HIV-1 Vpr and p21 restrict LINE-1 mobility

A Baseline Cellular Antiviral State Is Maintained by cGAS and Its Most Frequent Naturally Occurring Variant rs610913

Production and titration of lentiviral vectors

Recombinant protein production from stable mammalian cell lines and pools

Host determinants of HIV-1 control in African Americans

Lentiviral Vector Mediated Transgenesis

Generation of stable, high-producing cho cell lines by lentiviral vector-mediated gene transfer in serum-free suspension culture

Homology-based identification of capsid determinants that protect HIV1 from human TRIM5α restriction

Functional analysis and structural modeling of human APOBEC3G reveal the role of evolutionarily conserved elements in the inhibition of human immunodeficiency virus type 1 infection and Alu transposition

Studies on lentiviral-mediated transgenesis