Publications associées (214)

Label-Free Quantification Proteomics for the Identification of Mesenchymal Stromal Cell Matrisome Inside 3D Poly(Ethylene Glycol) Hydrogels

Matthias Lütolf, Yannick Robert Devaud, Martin Ehrbar

Cells modulate the functional properties of their environment by depositing extracellular matrix (ECM) proteins during biological processes in vivo and in vitro. Despite the ECMs central role in tissue formation, its quantification in hydrogels like Matrig ...
WILEY2018

Composite Double-Network Hydrogels To Improve Adhesion on Biological Surfaces

Dominique Pioletti, Pierre-Etienne Bourban, Christophe Moser, Peyman Karami, Andreas Schmocker, Azadeh Khoushabi, Céline Samira Wyss, Martin Broome

Despite the development of hydrogels with high mechanical properties, insufficient adhesion between these materials and biological surfaces significantly limits their use in the biomedical field. By controlling toughening processes, we designed a composite ...
2018

Beneficial effects of Human Mesenchymal Stromal Cells on Porcine Hepatocyte Viability and Albumin Secretion

Sandrine Gerber, François Rémi Pierre Noverraz, Solène Marcelle Françoise Marie Passemard, Luca Szabó, Aurélien Thomas

Porcine hepatocytes transplanted during acute liver failure might support metabolic functions until the diseased liver recovers its function. Here, we isolated high numbers of viable pig hepatocytes and evaluated hepatocyte functionality after encapsulatio ...
2018

Synthesis strategies to extend the variety of alginate-based hybrid hydrogels for cell microencapsulation

Sandrine Gerber, François Rémi Pierre Noverraz, Jutta Christine Wandrey, Solène Marcelle Françoise Marie Passemard, Luca Szabó

The production of hydrogel microspheres (MS) for cell immobilization, maintaining the favorable properties of alginate gels but presenting enhanced performance in terms of in vivo durability and physical properties, is desirable to extend the therapeutic p ...
Amer Chemical Soc2017

Influence of the Linker Length on the Cytotoxicity of Homobinuclear Ruthenium(II) and Gold(I) Complexes

Paul Joseph Dyson, Rosario Scopelliti, Mylène Soudani, Emilia Paunescu, Lucinda Kate Batchelor

Dinudear metal complexes have emerged as a promising class of anticancer compounds with the ability to cross-link biomolecular targets. Here, we describe two novel series of phosphine-linked dinudear ruthenium(II) p-cyrnene and gold(I) complexes, in which ...
2017

Site-Specific Polymer Attachment to HR2 Peptide Fusion Inhibitors against HIV-1 Decreases Binding Association Rates and Dissociation Rates Rather Than Binding Affinity

Harm-Anton Klok, Frederik Roman Wurm, Maarten Danial

A popular strategy for overcoming the limited plasma half-life of peptide heptad repeat 2 (HR2) fusion inhibitors against HIV-1 is conjugation with biocompatible polymers such as poly(ethylene glycol) (PEG). However, despite improved resistance to proteoly ...
2017

Microencapsulation of hepatocytes and mesenchymal stem cells for therapeutic applications

Sandrine Gerber, Jutta Christine Wandrey, Redouan Mahou

Encapsulated hepatocyte transplantation and encapsulated mesenchymal stem cell transplantation are newly developed potential treatments for acute and chronic liver diseases, respectively. Cells are microencapsulated in biocompatible semi-permeable alginate ...
Springer Science+Business Media2017

Charge-transfer and impulsive electronic-to-vibrational energy conversion in ferricyanide: ultrafast photoelectron and transient infrared studies'

Majed Chergui, Christopher Alexander Arrell, José Javier Pancracio Ojeda Andara, Luca Longetti

The photophysics of ferricyanide in H2O, D2O and ethylene glycol was studied upon excitation of ligand-to-metal charge transfer (LMCT) transitions by combining ultrafast photoelectron spectroscopy (PES) of liquids and transient vibrational spectroscopy. Up ...
Royal Society of Chemistry2017

Effects of Grafting Density and Film Thickness on the Adhesion of Staphylococcus epidermidis to Poly(2-hydroxy ethyl methacrylate) and Poly(poly(ethylene glycol)methacrylate) Brushes

Harm-Anton Klok, Sorin Alexandru Ibanescu

Thin polymer films that prevent the adhesion of bacteria are of interest as coatings for the development of infection-resistant biomaterials. This study investigates the influence of grafting density and film thickness on the adhesion of Staphylococcus epi ...
Wiley-Blackwell2016

Influence of Fluorinated Surfactant Composition on the Stability of Emulsion Drops

Esther Amstad, Gianluca Nicolas Etienne, Michael David Kessler

Aqueous drops of a well-defined size are often used as small containers for conducting chemical and biochemical reactions, cell assays and as templates to produce microparticles. To prevent their coalescence, they must be stabilized, for example, using sur ...
Wiley-Blackwell2016

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