Publications associées à Récepteur transmembranaire

Rules and mechanisms governing G protein coupling selectivity of GPCRs

Bruno Emanuel Ferreira De Sousa Correia, Pablo Gainza Cirauqui

G protein-coupled receptors (GPCRs) convert extracellular stimuli into intracellular signaling by coupling to heterotrimeric G proteins of four classes: Gi/o, Gq, Gs, and G12/13. However, our understanding of the G protein selectivity of GPCRs is incomplet ...

Cambridge2023

Mechanical Properties and Nanomotion of BT-20 and ZR-75 Breast Cancer Cells Studied by Atomic Force Microscopy and Optical Nanomotion Detection Method

Sandor Kasas, María Inés Villalba

Cells of two molecular genetic types of breast cancer-hormone-dependent breast cancer (ZR-75 cell line) and triple-negative breast cancer (BT-20 cell line)-were studied using atomic force microscopy and an optical nanomotion detection method. Using the Pea ...

Basel2023

Significance of Receptor Mobility in Multivalent Binding on Lipid Membranes

Maartje Martina Cornelia Bastings, Diana Kornelia Morzy

Numerous key biological processes rely on the concept of multivalency, where ligands achieve stable binding only upon engaging multiple receptors. These processes, like viral entry or immune synapse formation, occur on the diffusive cellular membrane. One ...

WILEY-V C H VERLAG GMBH2022

Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis

Didier Trono, Laurence Gouzi Abrami, Evaristo Jose Planet Letschert, Julien Léonard Duc, Laia Simo Riudalbas, Sandra Eloise Kjeldsen, Alexandre Coudray, Sagane Dind

The treatment of colorectal cancer (CRC) is an unmet medical need in absence of early diagnosis. Here, upon characterizing cancer-specific transposable element-driven transpochimeric gene transcripts (TcGTs) produced by this tumor in the SYSCOL cohort, we ...

2022

Computational rewiring of allosteric pathways reprograms GPCR selective responses to ligands

Patrick Daniel Barth, Mahdi Hijazi, Aurélien Laurent Jean-Charles Oggier, Dániel Kéri

G-protein-coupled receptors (GPCRs) are the largest class of cell surface receptors and drug targets, and respond to a wide variety of chemical stimuli to activate diverse cellular functions. Understanding and predicting how ligand binding triggers a speci ...

bioRxiv2022

The matricellular protein Drosophila Cellular Communication Network Factor is required for synaptic transmission and female fertility

Evelyne Ruchti, Brian Donal McCabe

Within the extracellular matrix, matricellular proteins are dynamically expressed nonstructural proteins that interact with cell surface receptors, growth factors, and proteases, as well as with structural matrix proteins. The cellular communication networ ...

Bethesda2022

Method and system for determining intracellular mediators' activity

Philippe Renaud, Horst Vogel, Thamani Dahoun, Margaux Catherine Marie Duchamp

A method for determining the presence of a molecule coupled to the cytoplasmic side of a cellular membrane is disclosed. The method is implemented in a microfluidic setting and is particularly suitable for determining the presence and/or the activity of a ...

2022

Microfluidic T Cell Selection by Cellular Avidity

Li Tang, Armand Kurum, Alexandre Harari

No T cell receptor (TCR) T cell therapies have obtained clinical approval. The lack of strategies capable of selecting and recovering potent T cell candidates may be a contributor to this. Existing protocols for selecting TCR T cell clones for cell therapi ...

WILEY2022

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Récepteur transmembranaire

Rules and mechanisms governing G protein coupling selectivity of GPCRs

Mechanical Properties and Nanomotion of BT-20 and ZR-75 Breast Cancer Cells Studied by Atomic Force Microscopy and Optical Nanomotion Detection Method

Rational design of protein switches: applications in synthetic biology and cancer immunotherapy

Selective integrin targeting with DNA-based nanomaterials

Significance of Receptor Mobility in Multivalent Binding on Lipid Membranes

Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis

Computational rewiring of allosteric pathways reprograms GPCR selective responses to ligands

The matricellular protein Drosophila Cellular Communication Network Factor is required for synaptic transmission and female fertility

Method and system for determining intracellular mediators' activity

Microfluidic T Cell Selection by Cellular Avidity

Graph Chatbot

Chattez avec Graph Search

Rules and mechanisms governing G protein coupling selectivity of GPCRs

Rational design of protein switches: applications in synthetic biology and cancer immunotherapy

Mechanical Properties and Nanomotion of BT-20 and ZR-75 Breast Cancer Cells Studied by Atomic Force Microscopy and Optical Nanomotion Detection Method

Selective integrin targeting with DNA-based nanomaterials

Significance of Receptor Mobility in Multivalent Binding on Lipid Membranes

Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis

Computational rewiring of allosteric pathways reprograms GPCR selective responses to ligands

The matricellular protein Drosophila Cellular Communication Network Factor is required for synaptic transmission and female fertility

Method and system for determining intracellular mediators' activity

Microfluidic T Cell Selection by Cellular Avidity