Publications associées à Hypokinesia

Gait speed in clinical and daily living assessments in Parkinson’s disease patients: performance versus capacity

Kamiar Aminian, Farzin Dadashi, Arash Atrsaei, Benoît Mariani

Gait speed often referred as the sixth vital sign is the most powerful biomarker of mobility. While a clinical setting allows the estimation of gait speed under controlled conditions that present functional capacity, gait speed in real-life conditions prov ...

2021

Cell-type-specific nicotinic input disinhibits mouse barrel cortex during active sensing

Carl Petersen, Sylvain Crochet, Célia Roxane Gasselin, Benoît Hohl

Fast synaptic transmission relies upon the activation of ionotropic receptors by neurotransmitter release to evoke postsynaptic potentials. Glutamate and GABA play dominant roles in driving highly dynamic activity in synaptically connected neuronal circuit ...

CELL PRESS2021

On Modeling Glottal Source Information for Phonation Assessment in Parkinson's Disease

Mathew Magimai Doss, Julian David Fritsch

Parkinson's disease produces several motor symptoms, including different speech impairments that are known as hypokinetic dysarthria. Symptoms associated to dysarthria affect different dimensions of speech such as phonation, articulation, prosody, and inte ...

ISCA-INT SPEECH COMMUNICATION ASSOC2021

MRI-based brain volumetry and retinal optical coherence tomography as the biomarkers of outcome in acute methanol poisoning

Tobias Kober, Bénédicte Marie Maréchal

Background: Basal ganglia lesions are typical findings on magnetic resonance imaging (MRI) of the brain in survivors of acute methanol poisoning. However, no data are available on the association between the magnitude of damaged brain regions, serum concen ...

ELSEVIER2020

A computational biophysical model of thalamic and reticular nucleus microcircuitry: from neurons to emergent network dynamics

Elisabetta Iavarone

The thalamus, once believed to be a simple relay station between the body periphery and the neocortex, has started to be recognized as a key player in higher-order functions, such as attention. It participates in the transition between brain states, such a ...

EPFL2020

MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients

Lijing Xin, Kim Do, Daniella Dwir, Basilio Giangreco

ious mechanisms involved in schizophrenia pathophysiology, such as dopamine dysregulation, glutamate/NMDA receptor dysfunction, neuroinflammation or redox imbalance, all appear to converge towards an oxidative stress "hub" affecting parvalbumine interneuro ...

2020

Excitatory/inhibitory neuronal metabolic balance in mouse hippocampus upon infusion of [U-C-13(6)]glucose

Rolf Gruetter, Bernard Lanz, Hongxia Lei, Carole Poitry-Yamate, Antoine Timothée Cherix, Guillaume Donati, Blanca Lizarbe Serra

Hippocampus plays a critical role in linking brain energetics and behavior typically associated to stress exposure. In this study, we aimed to simultaneously assess excitatory and inhibitory neuronal metabolism in mouse hippocampus in vivo by applying (18) ...

2021

Multi T1-weighted contrast MRI with fluid and white matter suppression at 1.5 T

Tobias Kober, Giulio Gambarota

Introduction: The fluid and white matter suppression sequence (FLAWS) provides two T1-weighted co-registered datasets: a white matter (WM) suppressed contrast (FLAWS1) and a cerebrospinal fluid (CSF) suppressed contrast (FLAWS2). FLAWS has the potential to ...

ELSEVIER SCIENCE INC2019

Analysis of patient-specific stimulation with segmented leads in the subthalamic nucleus

Philippe Renaud, André Mercanzini, Thuy Anh Khoa Nguyen

Objective Segmented deep brain stimulation leads in the subthalamic nucleus have shown to increase therapeutic window using directional stimulation. However, it is not fully understood how these segmented leads with reduced electrode size modify the volume ...

PUBLIC LIBRARY SCIENCE2019

GABA and glutamate moderate beta-amyloid related functional connectivity in cognitively unimpaired old-aged adults

Dimitri Nestor Alice Van De Ville, Maria Giulia Preti

Background: Effects of beta-amyloid accumulation on neuronal function precede the clinical manifestation of Alzheimer's disease (AD) by years and affect distinct cognitive brain networks. As previous studies suggest a link between beta-amyloid and dysregul ...

2019