Publications associées à Phosphorylation oxydative

Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125

Hilal Lashuel, Michel Prudent, Bruno Claude Daniel Fauvet, Mirva Hejjaoui, Filip Vercruysse, Yao Zhang

Despite increasing evidence that supports the role of different post-translational modifications (PTMs) in modulating α-synuclein (α-syn) aggregation and toxicity, relatively little is known about the functional consequences of each modification and whethe ...

2012

Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function

Patrick Aebischer, Bernard Schneider, Sylvain Eric Lengacher, Julien Dusonchet

Mitochondrial dysfunction and oxidative stress have been implicated in the etiology of Parkinsons disease. Therefore, pathways controlling mitochondrial activity rapidly emerge as potential therapeutic targets. Here, we explore the neuronal response to pro ...

Oxford University Press2012

Impaired myogenesis in estrogen-related receptor γ (ERRγ)-deficient skeletal myocytes due to oxidative stress

Johan Auwerx

Specialized contractile function and increased mitochondrial number and oxidative capacity are hallmark features of myocyte differentiation. The estrogen-related receptors (ERRs) can regulate mitochondrial biogenesis or mitochondrial enzyme expression in s ...

Federation Amer Soc Exp Biol2012

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

Johan Auwerx, Richardus Houtkooper, Ivan Stamenkovic, Michalina Janiszewska

Growth of numerous cancer types is believed to be driven by a subpopulation of poorly differentiated cells, often referred to as cancer stem cells (CSCs), that have the capacity for self-renewal, tumor initiation, and generation of nontumorigenic progeny. ...

Cold Spring Harbor Lab Press, Publications Dept2012

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

Johan Auwerx, Kristina Schoonjans, Carlos Canto Alvarez, Pénélope Andreux, Karl Gademann, Richardus Houtkooper, Eija Riitta Pirinen, Hiroyasu Yamamoto, Maaike Hélène Oosterveer, Pablo Jose Fernandez Marcos

As NAD(+) is a rate-limiting cosubstrate for the sirtuin enzymes, its modulation is emerging as a valuable tool to regulate sirtuin function and, consequently, oxidative metabolism. In line with this premise, decreased activity of PARP-1 or CD38-both NAD(+ ...

Elsevier2012

Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

Johan Auwerx, Kristina Schoonjans, Carlos Canto Alvarez, Pénélope Andreux, Norman Lionel Moullan, Eija Riitta Pirinen, Hiroyasu Yamamoto, Taoufiq Harach, Pablo Jose Fernandez Marcos, Ellen Helena Jeninga

Sirt3 is a mitochondrial sirtuin, predominantly expressed in highly metabolic tissues. Germline ablation of Sirt3 has major metabolic consequences, including increased susceptibility to metabolic damage and oxidative stress after high fat feeding. In order ...

2012

Biophotonic tool for sensing the dynamics of H2O2 extracellular release in stressed cells

Olivier Martin, Christian Santschi, Shourya Dutta Gupta

Hydrogen peroxide (H2O2) is known to play a multifaceted role in cell physiology mechanisms involving oxidative stress and intracellular signal transduction. Therefore, the development of analytical tools providing information on the dynamics of H2O2 gener ...

Spie-Int Soc Optical Engineering, Po Box 10, Bellingham, Wa 98227-0010 Usa2012

Self-Assembled Molecular Rafts at Liquid|Liquid Interfaces for Four-Electron Oxygen Reduction

Hubert Girault, Jiri Vanicek, Astrid Johana Olaya Avendano, Pierre-François Marie Brevet, Tomas Zimmermann

The self-assembly of the oppositely charged watersoluble porphyrins, cobalt tetramethylpyridinium porphyrin (CoTMPyP4+) and cobalt tetrasulphonatophenyl porphyrin (CoTPPS4−), at the interface with an organic solvent to form molecular “rafts”, provides an e ...

2012

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Phosphorylation oxydative

Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125

Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function

Impaired myogenesis in estrogen-related receptor γ (ERRγ)-deficient skeletal myocytes due to oxidative stress

Multidisciplinary Analysis of the Metabolic Shift to Lactate Consumption in CHO Cell Culture

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

Structural Role of RKS Motifs in Chromatin Interactions: A Molecular Dynamics Study of HP1 Bound to a Variably Modified Histone Tail

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

Biophotonic tool for sensing the dynamics of H2O2 extracellular release in stressed cells

Self-Assembled Molecular Rafts at Liquid|Liquid Interfaces for Four-Electron Oxygen Reduction

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Chattez avec Graph Search

Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function

Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125

Impaired myogenesis in estrogen-related receptor γ (ERRγ)-deficient skeletal myocytes due to oxidative stress

Multidisciplinary Analysis of the Metabolic Shift to Lactate Consumption in CHO Cell Culture

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

Structural Role of RKS Motifs in Chromatin Interactions: A Molecular Dynamics Study of HP1 Bound to a Variably Modified Histone Tail

Self-Assembled Molecular Rafts at Liquid|Liquid Interfaces for Four-Electron Oxygen Reduction

Biophotonic tool for sensing the dynamics of H2O2 extracellular release in stressed cells

Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis